daprodustat,GSK1278863

daprodustat,GSK1278863 Suppliers list
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-81148696 +86-15536356810
Email: 1022@dideu.com
Products Intro: Product Name:Daprodustat
CAS:960539-70-2
Purity:99.0% Package:1KG;0.1USD
Company Name: Hangzhou Hyper Chemicals Limited
Tel: +86-0086-57187702781 +8613675893055
Email: info@hyper-chem.com
Products Intro: Product Name:Daprodustat
CAS:960539-70-2
Purity:EP/USP Package:1KG;|5KG;|25KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:GSK1278863
CAS:960539-70-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:daprodustat,GSK1278863
CAS:960539-70-2
Purity:95%~99% Package:1ASSAYS;1USD
Company Name: Shochem(Shanghai) Co.,Ltd
Tel: 86-21-50800795
Email: info@shochem.com
Products Intro: Product Name:Daprodustat
CAS:960539-70-2
Purity:98% Package:10g;USD|1KG;USD

daprodustat,GSK1278863 manufacturers

  • Daprodustat
  • Daprodustat pictures
  • $0.00 / 1KG
  • 2024-09-07
  • CAS:960539-70-2
  • Min. Order: 1KG
  • Purity: EP/USP
  • Supply Ability: 1 ton
  • Daprodustat
  • Daprodustat pictures
  • $0.10 / 1KG
  • 2024-08-05
  • CAS:960539-70-2
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 1000Tons
  • Daprodustat
  • Daprodustat pictures
  • $0.00 / 1g
  • 2021-10-08
  • CAS:960539-70-2
  • Min. Order: 1g
  • Purity: 98%
  • Supply Ability: 100kgs

Related articles

  • Synthesis of Daprodustat
  • Daprodustat is synthesised using malonic acid as a raw material by Biginelli reaction, saponification and other reactions.
  • Dec 21,2023
daprodustat,GSK1278863 Basic information
Product Name:daprodustat,GSK1278863
Synonyms:daprodustat,GSK1278863;GSK1278863;Daprodustat;2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid;N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine;GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT;2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid;GSK1278863,daprodustat
CAS:960539-70-2
MF:C19H27N3O6
MW:393.43
EINECS:691-659-9
Product Categories:API
Mol File:960539-70-2.mol
daprodustat,GSK1278863 Structure
daprodustat,GSK1278863 Chemical Properties
Melting point 237-241oC
density 1.359±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), DMSO (Slightly)
pka3.44±0.10(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
daprodustat,GSK1278863 Usage And Synthesis
UsesDaprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.
Biological Activitydaprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.
in vitroin-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1].
references[1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71.
daprodustat,GSK1278863 Preparation Products And Raw materials
Tag:daprodustat,GSK1278863(960539-70-2) Related Product Information
N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2126458 ABT 702 Dihydrochloride Danirixin GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%