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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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| Products Intro: |
Product Name:Hydrocortisone Impurity 115
CAS:25848-69-5
Purity:99%HPLC Package:10mg、25mg、50mg、100mg
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| | Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?- Basic information |
| Product Name: | Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?- | | Synonyms: | Androstan-17-one, 3,7-dihydroxy-, (3β,5α,7β)-;Hydrocortisone Impurity 115 | | CAS: | 25848-69-5 | | MF: | C19H30O3 | | MW: | 306.4397 | | EINECS: | | | Product Categories: | | | Mol File: | 25848-69-5.mol |  |
| | Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?- Chemical Properties |
| Melting point | 241 °C(Solv: ethyl acetate (141-78-6)) | | Boiling point | 454.7±45.0 °C(Predicted) | | density | 1.158±0.06 g/cm3(Predicted) | | pka | 14.75±0.70(Predicted) |
| | Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?- Usage And Synthesis |
| Uses | 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3]. | | Definition | ChEBI: 7beta-hydroxyepiandrosterone is a 3beta-hydroxy steroid that is epiandrosterone carrying a hydroxy group at the 7beta position. It is an endogenous androgen metabolite that has been shown to exert neuroprotective effects. It has a role as a human metabolite, a neuroprotective agent, an estrogen receptor antagonist and an androgen. It is a 17-oxo steroid, a 7beta-hydroxy steroid, a 3beta-hydroxy steroid and an androstanoid. It is functionally related to an epiandrosterone. | | in vivo | 7β-Hydroxy-epi-androsterone (i.p., once a day for 7 days) displays anti-inflammatory effects in rat with DSS-induced colitis[3].
7β-Hydroxy-epi-androsterone (0.1 mg/kg s.c., b.i.d. for 10 days) shows protective effect against inflammatory neurodegeneration and glial cell death in Alzheimer's disease rats[4].
| Animal Model: | Rat with DSS-induced colitis[3] | | Dosage: | 0.01, 0.1 and 1 mg/kg | | Administration: | Intraperitoneal injection (i.p.), once a day for 7 days. | | Result: | Increased in COX-2 and PGE synthase expression.
Increased colonic tissue levels of 15d-PGJ2 levels.
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| | IC 50 | ERβ | | References | [1] Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30.
[2] Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77(5):542-51. DOI:10.1016/j.steroids.2012.01.019
[3] Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):255-62. DOI:10.1016/j.jsbmb.2007.12.014
[4] Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8. DOI:10.1016/j.nbd.2003.11.001 |
| | Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?- Preparation Products And Raw materials |
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