| Company Name: |
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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| Tel: |
028-83379370 13880556291 |
| Email: |
tcy@tcypharm.com |
| Products Intro: |
Product Name:5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole
CAS:1254473-74-9
Purity:99% HPLC Package:5KG;1KG
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| Company Name: |
Shanghai SPAR pharmaceutical technology co., LTD
|
| Tel: |
021000000 |
| Email: |
admin@jingshipharmatech.com |
| Products Intro: |
Product Name:5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole
CAS:1254473-74-9
Purity:95% HPLC Package:1g：5g:10g：25g:50g：100g:250g：500g:1Kg：100Kg:
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| | 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole Basic information | | Synthesis |
| | 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole Chemical Properties |
| Boiling point | 323.0±15.0 °C(Predicted) | | density | 1.046±0.06 g/cm3(Predicted) | | pka | 13.63±0.40(Predicted) |
| | 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole Usage And Synthesis |
| Synthesis | 1H-indazol-5-ol (1.00 g, 7.45 mmol)
dissolved in 20 mL of anhydrous methylene chloride was added to a 100 mL round bottom flask.
Tert-butyldimethylsilyl chloride (1.69 g, 11.18 mmol) and imidazole (0.51 g, 7.45 mmol) were
added to the reaction vessel producing a cloudy white mixture. Lastly, N,Ndiisopropylethylamine
(1.95 mL, 11.18 mmol) was added, giving a clear solution. The reaction
was stirred overnight at room temperature.
Methylene chloride was used to dilute the reaction
followed by washing with NaCl (2x). The organic layer was dried over MgSO4, concentrated in
vacuo, and purified using flash chromatography with a 20% EtOAc/Hexane gradient to give 5-
((tert-butyldimethylsilyl)oxy)-1H-indazole (5a) (1.72g, 93%). 1H NMR (DMSO – d6, 400 MHz)
δ: 12.91 (s, 1H), 7.92 (s, 1H), 7.41 (d, J=9.0 Hz, 1H), 7.12 (d, J=1.5 Hz, 1H), 6.91 (dd, J = 8.8,
2.3 Hz, 1H), 0.96 (s, 9H), 0.18 (s, 6H). |
| | 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1H-Indazole Preparation Products And Raw materials |
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