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| | XMU-MP-1 Basic information |
| Product Name: | XMU-MP-1 | | Synonyms: | XMU-MP-1;PubChem ID: 121499143;CS-2590;4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide;Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-;4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1;XUM-MP- 1 | | CAS: | 2061980-01-4 | | MF: | C17H16N6O3S2 | | MW: | 416.48 | | EINECS: | | | Product Categories: | API | | Mol File: | 2061980-01-4.mol |  |
| | XMU-MP-1 Chemical Properties |
| Boiling point | 714.8±70.0 °C(Predicted) | | density | 1.523±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | ≥41.6 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH | | form | powder | | pka | 9.77±0.12(Predicted) | | color | white to beige |
| | XMU-MP-1 Usage And Synthesis |
| Description | XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury. | | Uses | XMU-?MP-?1 an MST1/2 inhibitor. | | storage | Store at -20°C | | references | 1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108. |
| | XMU-MP-1 Preparation Products And Raw materials |
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