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4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid Suppliers list
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Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:4-Hydroxyphenylacetic acid
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4-Hydroxyphenylacetic acid Basic information
Description Referrence
Product Name:4-Hydroxyphenylacetic acid
Synonyms:(p-hydroxyphenyl)-aceticaci;4-carboxymethylphenol;4-Hydroxybenzeneacetic acid;4-Hydroxyphenylacetic acid Vetec(TM) reagent grade, 98%;Arbidol Impurity F HCl;Levothyroxine Sodium Impurity d;NSC 27460;Acetic acid, (p-hydroxyphenyl)-
Product Categories:C8Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels;Aromatic Phenylacetic Acids and Derivatives;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical;alcohol| carboxylic acid;1
Mol File:156-38-7.mol
4-Hydroxyphenylacetic acid Structure
4-Hydroxyphenylacetic acid Chemical Properties
Melting point 148-151 °C(lit.)
Boiling point 234.6°C (rough estimate)
density 1.2143 (rough estimate)
refractive index 1.4945 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility 50g/l
form Crystalline Powder
color White to cream or light tan
PH2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 1448766
CAS DataBase Reference156-38-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry SystemBenzeneacetic acid, 4-hydroxy- (156-38-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
RTECS AI2680000
Hazard Note Irritant
HS Code 29182990
MSDS Information
4-Hydroxyphenylacetic acid English
SigmaAldrich English
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4-Hydroxyphenylacetic acid Usage And Synthesis
Description4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.
  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.
Chemical Propertieswhite to cream or light tan crystalline powder
UsesA compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
UsesIt is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes.
DefinitionChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
Purification MethodsCrystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]
Tag:4-Hydroxyphenylacetic acid(156-38-7) Related Product Information
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