伪-HYDROXYLINOLEIC ACID
| 中文名称 | 伪-HYDROXYLINOLEIC ACID |
|---|---|
| 中文同义词 | 伪-HYDROXYLINOLEIC ACID;Α-羟基油酸;化合物 T13430;Α-羟基油酸 |
| 英文名称 | Voxilaprevir |
| 英文同义词 | ABTL 0812;ABTL0812;ABTL-0812;α-Hydroxylinoleic acid;2-hydroxylinoleic acid);ABTL0812 (ABTL 0812;(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid;ABTL 0812;2-HYDROXYLINOLEIC ACID |
| CAS号 | 57818-44-7 |
| 分子式 | C18H32O3 |
| 分子量 | 296.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 57818-44-7.mol |
| 结构式 |  |
伪-HYDROXYLINOLEIC ACID 性质
| 沸点 | 409.7±30.0 °C(Predicted) |
|---|---|
| 密度 | 0.970±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：5 mg/ml（16.87 mM） |
| 酸度系数(pKa) | 3.85±0.21(Predicted) |
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。
| Target | Value |
|
Akt
() | |
|
mTOR
() |
ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells.
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.
Cell Viability Assay
| Cell Line: | Human lung fibroblast MRC5 and squamous non-small cell lung (NSCLC) H157 cells |
| Concentration: | 10, 30, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell viability of squamous NSCLC H157 cells, not lung fibroblast cell line MRC-5. |
ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts.
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.
| Animal Model: | Athymic female nude mice bearing MiaPaca2 and A549 xenograft models |
| Dosage: | 120 mg/kg |
| Administration: | Administered by oral gavage; 5 times per week for 33 days |
| Result: | Induced ER stress in human lung and pancreatic xenografts. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-U00141 | ABTL-0812 | 1 mg | 1704元 | |
| 2024/04/30 | HY-U00141 | 伪-HYDROXYLINOLEIC ACID ABTL-0812 | 57818-44-7 | 5mg | 3750元 |