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| | Bisindolylmaleimide V Basic information |
| Product Name: | Bisindolylmaleimide V | | Synonyms: | 1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045;1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione;1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione;1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione;3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione;3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione;BISINDOLYLMALEIMIDE V;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione | | CAS: | 113963-68-1 | | MF: | C21H15N3O2 | | MW: | 341.36 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 113963-68-1.mol |  |
| | Bisindolylmaleimide V Chemical Properties |
| Melting point | >260 °C | | Boiling point | 655.7±55.0 °C(Predicted) | | density | 1.450±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble | | form | solid | | pka | 15.89±0.30(Predicted) | | color | Orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 113963-68-1(CAS DataBase Reference) |
| | Bisindolylmaleimide V Usage And Synthesis |
| Description | Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4. | | Definition | ChEBI: Ro 31-6045 is a member of indoles. | | References | 1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135
2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71
3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771
4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177 |
| | Bisindolylmaleimide V Preparation Products And Raw materials |
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