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| | GSK-626616 Basic information |
| Product Name: | GSK-626616 | | Synonyms: | GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase | | CAS: | 1025821-33-3 | | MF: | C18H10Cl2N4OS | | MW: | 401.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1025821-33-3.mol |  |
| | GSK-626616 Chemical Properties |
| Melting point | 281 - 282oC | | Boiling point | 574.8±60.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly, Heated), Methanol (Slightly) | | pka | -0.94±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Light Yellow |
| | GSK-626616 Usage And Synthesis |
| Uses | GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable. | | storage | Store at +4°C |
| | GSK-626616 Preparation Products And Raw materials |
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