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| | NVS-PAK1-1 Basic information |
| Product Name: | NVS-PAK1-1 | | Synonyms: | NVS-PAK1-1;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-;NVS-PAK1-1 >=98% (HPLC);NVS-PAK11Chemicalbook;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11 | | CAS: | 1783816-74-9 | | MF: | C23H25ClF3N5O | | MW: | 479.93 | | EINECS: | | | Product Categories: | API | | Mol File: | 1783816-74-9.mol |  |
| | NVS-PAK1-1 Chemical Properties |
| Boiling point | 697.8±55.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml | | pka | 14.02±0.40(Predicted) | | form | powder | | color | white to beige |
| | NVS-PAK1-1 Usage And Synthesis |
| Uses | NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors. | | Biochem/physiol Actions | NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc | | storage | Store at -20°C |
| | NVS-PAK1-1 Preparation Products And Raw materials |
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