|
|
| | 3'-Deoxycytidine Basic information |
| Product Name: | 3'-Deoxycytidine | | Synonyms: | 3-DC;3’-deoxy-cytidin;3'-DEOXYCYTIDINE;3'-deoxycytidine free base;3'-Deoxy-D-cytidine;3''-Deoxycytidine (and/or unspecified salts);1-(3-Deoxy-β-D-erythro-pentofuranosyl)cytosine;4-amino-1-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | | CAS: | 7057-33-2 | | MF: | C9H13N3O4 | | MW: | 227.22 | | EINECS: | | | Product Categories: | | | Mol File: | 7057-33-2.mol |  |
| | 3'-Deoxycytidine Chemical Properties |
| Melting point | 230-232 °C | | Boiling point | 497.6±55.0 °C(Predicted) | | density | 1.73±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 14.01±0.60(Predicted) | | InChI | InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-6(14)3-5(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 | | InChIKey | ZHHOTKZTEUZTHX-SHYZEUOFSA-N | | SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)C1 |
| RTECS | HA3830000 | | HS Code | 29389090 |
| | 3'-Deoxycytidine Usage And Synthesis |
| Uses | 3'-Deoxycytidine is an inhibitor of nucleolar RNA synthesis but does not affect the appearance of mRNA. Displayed inhibitory properties against the replication of hepatitis C virus-like RNA template. | | Biological Activity |
3'-Deoxycytidine is a pyrimidine analog of cordycepin. The structures of cordycepin and 3'-deoxycytidine resemble adenosine and cytidine except for the altered 3' position in the ribose moiety, where hydrogen is substituted for the hydroxyl group. 3'-deoxycytidine affects similar to that of cordycepin on nucleolar RNA formation and has approximately the same level of activity as the adenosine analog. 3'-deoxycytidine, like cordycepin, enters cells and is phosphorylated by the appropriate enzymes. 3'-Deoxycytidine shares with cordycepin the ability to inhibit nucleolar RNA synthesis, but it does not affect the appearance of mRNA. Neither compound affects heterogeneous nuclear RNA (HnRNA)[1].
| | References | [1] Herbert T. Abelson, Sheldon Penman. “Messenger RNA formation: Resistance to inhibition by 3′-deoxycytidine.” Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 277 1 (1972): Pages 129-133. |
| | 3'-Deoxycytidine Preparation Products And Raw materials |
|