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Chlorophacinone

Chlorophacinone Basic information
Product Name:Chlorophacinone
Synonyms:((4-Chlorphenyl)-1-phenyl)-acetyl-1,3-indandion;1-(4-Chlorphenyl)-1-phenyl-acetyl-indan-1,3-dion;1,3-Indandione, 2-[(p-chlorophenyl)phenylacetyl]-;1H-Indene-1,3(2H)-dione, 2-[(4-chlorophenyl)phenylacetyl]-;2-((p-chlorophenyl)phenylacetyl)-1,3-indandione;2-((p-chlorophenyl)phenylacetyl)-3-indandione;2(2-(4-Chloor-fenyl-2-fenyl)-acetyl)-indaan-1,3-dion;2(2-(4-chlor-phenyl-2-phenyl)acetyl)indan-1,3-dion
CAS:3691-35-8
MF:C23H15ClO3
MW:374.82
EINECS:223-003-0
Product Categories:INSECTICIDE;Alpha sort;C;CAlphabetic;CHPesticides&Metabolites;Pesticides;Pesticides&Metabolites;Rodenticides
Mol File:3691-35-8.mol
Chlorophacinone Structure
Chlorophacinone Chemical Properties
Melting point 138°
Boiling point 490.38°C (rough estimate)
density 1.1517 (rough estimate)
refractive index 1.4585 (estimate)
Fp >100 °C
storage temp. -20°C
pka2.61±0.10(Predicted)
Merck 13,2171
NIST Chemistry ReferenceChlorophacinone(3691-35-8)
EPA Substance Registry SystemChlorophacinone (3691-35-8)
Safety Information
Hazard Codes T+;N,N,T+
Risk Statements 23-27/28-48/24/25-50/53
Safety Statements 36/37-45-60-61
RIDADR UN 2811
RTECS NK5335000
HazardClass 6.1(a)
PackingGroup I
HS Code 29147000
Hazardous Substances Data3691-35-8(Hazardous Substances Data)
ToxicityLD50 oral in rabbit: 50mg/kg
MSDS Information
Chlorophacinone Usage And Synthesis
DescriptionChlorophacinone is produced by condensation of 1- phenyl-1-(4-chlorophenyl) acetone with dimethyl phthalate in the presence of sodium methoxide (31).
This compound was introduced in 1961 and is now widely used in Europe, the United States, and elsewhere. It is used in baits against norway rats at a concentration of 0.005–0.01%. Bait containing 0.025% chlorophacinone gave a complete kill of house mice after a 7-d feeding period but, in other tests, survivors were recorded following 10 and 21 days of feeding (5). Chlorophacinone acts as an uncoupler of oxidative phosphorylation as well as an anticoagulant (32), which is unusual among this group of compounds.
Chemical PropertiesChlorophacinone is a highly toxic crystalline solid.
UsesChlorophacinone (CPN) is an anticoagulant rodenticide widely used to control rodent infestations.
UsesAnticoagulant rodenticide.
General DescriptionCrystals. Commercially available as oil concentrate and as dust concentrate. Used as an anticoagulant rodenticide. Chronic acting, multiple dose rodenticide.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileFire may produce irritating or poisonous gases.
Health HazardChlorphacinon is highly toxic orally and by skin absorption. The probable oral lethal dose for humans is less than 5 mg/kg to 50 mg/kg, or between a taste (less than 7 drops) and 1 teaspoonful for a 150 lb. (70 kg) person.
Health HazardHighly toxic anticoagulant rodenticide; lowchlorine content but highly toxic; exhibitsacute, delayed, and chronic poisoning;symptoms include bleeding of nose andgum, blood in cough, urine, and stool,abdominal pain and hemorrhage; can beabsorbed through skin causing systemicpoisoning; ingestion of 1–2 g is estimatedto be fatal dose for adult human; U.S. EPAlisted extremely hazardous substance.
LD50 oral (rat): ~2 mg/kg
LD50 oral (mouse): ~1 mg/kg
LD50 oral (rabbit): 50 mg/kg
LD50 skin (rabbit): 200 mg/kg.
Fire Hazard(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irriating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated Chlorphacinon emits toxic fumes of chlorides.
Agricultural UsesRodenticide: This material is an anticoagulant rodenticide used around livestock and also on crops such as artichokes. Some brands are labeled for use indoors and outdoors for the control of mice, rats, moles, muskrats, voles and vampire bats. Not approved for use in EU countries. Registered for use in the U.S. There are 24 global suppliers.
Trade nameAFNOR®; CAID®; DELTA®; DRAT RAT BAIT®; ENDORATS®; LIPHADIONE®; LM 91®; MICROZUL®; MURIOL®; PARTOX®[C]; QUICK®; RAMUCIDE®; RANAC®; RATOMET®; RAVIAC®; ROZOL®[C]; TOPITOX®
Safety ProfilePoison by ingestion and skin contact. Human systemic effects by ingestion: vascular changes. A pesticide. When heated to decomposition it emits toxic fumes of Cl-.
Potential ExposureAgricultural Chemical. This material is an anticoagulant rodenticide. A potential danger to those involved in its manufacture, formulation, and application are at risk.
ShippingUN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Waste DisposalIncineration at high temperature with effluent gas scrubbing.
Chlorophacinone Preparation Products And Raw materials
Raw materialsDimethyl phthalate-->1-(4-Chlorophenyl)-1-phenylacetone-->2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID-->1,3-Indanedione-->Chlorobenzene
Tag:Chlorophacinone(3691-35-8) Related Product Information
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