- (4-Aminophenyl)acetic acid
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- $5.00 / 1KG
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2024-01-14
- CAS:1197-55-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 4-Aminophenylacetic acid
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- $0.00 / 25drums
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2023-10-22
- CAS:1197-55-3
- Min. Order: 1drums
- Purity: 98.5%min.
- Supply Ability: 10tons
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| 4-Aminophenylacetic acid Basic information |
| 4-Aminophenylacetic acid Chemical Properties |
Hazard Codes | Xi,Xn | Risk Statements | 36/37/38-20/21/22 | Safety Statements | 22-24/25-36-26 | WGK Germany | 3 | RTECS | AF3550000 | F | 13 | TSCA | Yes | HazardClass | IRRITANT | HS Code | 29224995 | Toxicity | mouse,LD50,intraperitoneal,3500mg/kg (3500mg/kg),Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958. |
| 4-Aminophenylacetic acid Usage And Synthesis |
Chemical Properties | light yellow to beige powder. Soluble in alcohols and alkalis, slightly soluble in hot water. | Uses | 4-Aminophenylacetic acid is used as a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1. It can be detected using HPLC, NMR techniques. | Preparation | p-aminophenylacetic acid is obtained by the reduction of 4-nitrophenylacetic acid. In a reactor, water, 4-nitrophenylacetic acid, and acetic acid are added. The mixture is stirred and heated to 90-95℃. Iron powder is added in portions and refluxed for 2 hours. The mixture is cooled to 40-50℃ and neutralized with sodium carbonate to pH=9, then filtered. The filtrate is further neutralized with acetic acid until pH=4, resulting in the precipitation of 4-aminophenylacetic acid. The yield is 95%. | benefits |
4-Aminophenylacetonitrile (4-APAN) is an arylacetonitrile and an active substrate for arylacetonitrilase, which gives 4-aminophenylacetic acid (4-APAA) on hydrolysis. 4-APAA is a precursor of 4-acetylaminophenylacetic acid, used in treating rheumatoid arthritis and actarit drugs. 4-APAA also possesses tuberculostatic activity and is helpful as a fibrinolysis inhibitor. In addition to the medical importance of this acid, several derivatives and compounds obtained from 4-APAA showed antimicrobial activity[1].
| Purification Methods | Crystallise the acid from hot water (60-70mL/g). [Beilstein 14 III 1182.] | References | [1] Neerja Thakur. “Bioprocess Development for the Synthesis of 4-Aminophenylacetic Acid Using Nitrilase Activity of Whole Cells of Alcaligenes faecalis MTCC 12629.” Catalysis Letters 149 10 (2019): 2854–2863.
| References | [1] BEDAIRAHMED H. Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.[J]. Acta Pharmaceutica, 2006, 56 3: 273-284. [2] MENGYIFAN ZareRichard N GnanamaniElumalai. One-Step Formation of Pharmaceuticals Having a Phenylacetic Acid Core Using Water Microdroplets.[J]. Journal of the American Chemical Society, 2023, 145 14: 7724-7728. DOI:10.1021/jacs.3c00773. |
| 4-Aminophenylacetic acid Preparation Products And Raw materials |
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