2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:BRD6989 CAS:642008-81-9 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:BRD6989 CAS:642008-81-9 Purity:99.43% Package:5mg;39USD\|10mg;59USD\|25mg;123USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:BRD6989 CAS:642008-81-9 Purity:98% Package:10mg Remarks:V17001

Company Name:	Nanjing Doge Biomedical Technology Co., Ltd
Tel:	+86-25-58227606 +86-15305155328
Email:	sales@dogechemical.com
Products Intro:	Product Name:2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile CAS:642008-81-9 Package:5g;100g;1KG;25KG

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:BRD6989 CAS:642008-81-9 Purity:99.43% Package:5mg;39USD\|10mg;59USD\|25mg;123USD

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile manufacturers

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Basic information

Product Name:	2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Synonyms:	2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile;BRD6989 (BRD-6989;2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile;BRD6989;BRD6989 >=98% (HPLC);CDK8,BRD 6989,Inhibitor,inhibit,CDK19,IL-10,inflammatory,BRD6989,Cyclin dependent kinase,BRD-6989,BMDCs,Interleukin Related,cortistatin-A,CDK;BRD6989, 10 mM in DMSO;BRD6989 ，S0771
CAS:	642008-81-9
MF:	C16H16N4
MW:	264.33
EINECS:
Product Categories:
Mol File:	642008-81-9.mol

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Chemical Properties

Safety Information

MSDS Information

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Usage And Synthesis

Uses	BRD 6989, is a small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells.
Definition	ChEBI: 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines.
Biological Activity	BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) th at upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μM, respectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM.
IC 50	CDK8: ~200 nM (IC₅₀); recombinant CDK8: ~0.5 μM (IC₅₀); recombinant CDK19: >30 μM (IC₅₀); IL-10
storage	Store at +4°C

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile Preparation Products And Raw materials

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