ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Forensic and veterinary standards >(-)-COTININE

(-)-COTININE

(-)-COTININE Suppliers list
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:(-)-Cotinine
CAS:486-56-6
Purity:95%
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:486-56-6
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: 86-021-61999440
Email: contact@trustwe.com
Products Intro: Product Name:(-)-COTININE
CAS:486-56-6
Purity:98% Package:Package as requetsed
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel: 13580539051
Email: joe@yuhengpharm.com
Products Intro: Product Name:(5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
CAS:486-56-6
Purity:0.97 Package:1KG;25KG
Company Name: Target Molecule Corp
Tel: 781-999-5354 18019718960
Email: marketing@targetmol.com
Products Intro: Product Name:(-)-Cotinine;(S)-Cotinine;NIH-10498;Cotinine;S-(-)-Cotinine;S-(-)-Cotinine
CAS:486-56-6
Purity:99.79% Package:5 mg;10 mg;50 mg;100 mg;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY

Related articles

  • Mechanism of COTININE
  • Cotinine is the major metabolite of nicotine. In the liver, nicotine is rapidly metabolized to cotinine (70–80%) by CYP2A6 and....
  • Jan 12,2022
(-)-COTININE Basic information
Product Name:(-)-COTININE
Synonyms:Nicotine EP Impurity C ( Cotinine);L-COTININE;(-)-COTININE;COTININE;S-(-)-COTININE;(S)-(-)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE;[S]-1-METHYL-5-[3-PYRIDYL]-2-PYRROLIDINONE;S(-)-1-METHYL-5-(3-PYRIDYL)-2-PYRROLIDONE
CAS:486-56-6
MF:C10H12N2O
MW:176.22
EINECS:207-634-9
Product Categories:Inhibitors;Metabolites;Nicotine Derivatives;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Various Metabolites and Impurities
Mol File:486-56-6.mol
(-)-COTININE Structure
(-)-COTININE Chemical Properties
Melting point 40-42 °C(lit.)
Boiling point 250 °C150 mm Hg(lit.)
alpha [α]D20 -18~-22° (c=1, C2H5OH)
density 1.1102 (rough estimate)
refractive index 1.7110 (estimate)
Fp >230 °F
storage temp. Sealed in dry,2-8°C
pka4.72±0.12(Predicted)
optical activity[α]/D -21±2°, c = 1 in ethanol
Water Solubility Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Merck 14,2553
BRN 83099
Stability:Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.
EPA Substance Registry SystemCotinine (486-56-6)
Safety Information
Hazard Codes Xn,Xi,T,F
Risk Statements 22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 7-16-36/37-45-36-26
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS GN1925500
10
HS Code 29333990
Hazardous Substances Data486-56-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
(-)-COTININE Usage And Synthesis
DescriptionCotinine is the major metabolite of nicotine. In the liver, nicotine is rapidly metabolized to cotinine (70–80%) by CYP2A6 and to nornicotine (5%) by CYP2A6 and CYP2B6. With a half-life about 10-fold longer than that of nicotine (15–19 h for cotinine versus 2–3 h for nicotine), cotinine induces plasma concentrations of 1–3 mM in smokers. After administration to rats, cotinine levels in the brain reach fourfold those of nicotine at 4 h following injection. Cotinine is not biotransformed in the brain, allowing accumulation of this substance to levels greater than that of nicotine.
Like nicotine, cotinine is able to induce dopamine release in smokers and in superfused rat striatal slices in a dose- and calcium-dependent manner via the nicotinic receptors, but only at concentrations higher than those normally seen in smokers. Indeed, administration of cotinine to smokers at levels 10-fold that is seen following smoking had no observable effect, suggesting that cotinine is not neuroactive at doses found in smokers. However, cotinine also acts as an inhibitor for nicotine binding in rat brain via desensitization of the nicotinic receptor.
Chemical PropertiesColourless to Light Brown Solid
UsesA major metabolite of nicotine in humans
UsesA major metabolite of Nicotine (N412450) in humans. Carcinogen.
Usesantidepressant
Uses(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.
DefinitionChEBI: An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
Synthesis Reference(s)Synthetic Communications, 18, p. 1331, 1988 DOI: 10.1080/00397918808078800
Biological ActivityMajor metabolite of nicotine. Shown to activate a subpopulation of α 3/ α 6 β 2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo .
Environmental FateCotinine stimulates dopamine release in the nigrostriatal pathway by activating nicotinic acetylcholine receptors. However, its lower EC50 prevents significant activation of this pathway in smokers.
Toxicity evaluationCotinine has a vapor pressure of 3.8×10-4mmHg at 25 °C. Cotinine will be photochemically degraded with a half-life of 15 h. In sediment, cotinine is completely degraded to carbon dioxide within 72 h. It is not expected to bioaccumulate in aquatic organisms.
(-)-COTININE Preparation Products And Raw materials
Preparation ProductsNORNICOTINE, DL-(RG)
Tag:(-)-COTININE(486-56-6) Related Product Information
(R,S)-ORTHO-COTININE,(+/-)-O-COTININE TICRYNAFEN (R,S) COTININE-N-B-D-GLUCURONIDE, METHYL-D3 COTININE-N-(4-DEOXY-4,5-DIDEHYDRO)-§-D-GLUCURONID DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3, 99 ATOM % D,(+/-)-COTININE-D3,COTININE-D3 (N-METHYL-D3) (-)-COTININE N-OXIDE ANTI-COTININE TRANS-3'-HYDROXYCOTININE-N-BETA-D-GLUCURONIDE, METHYL-D3 N-(4-METHOXYBENZYL)COTININE 1-(4-METHOXYBENZYL)-3-ACETOXYNORCOTININE DL-Cotinine-methyl-D3,DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3,COTININE-D3 (N-METHYL-D3),(+/-)-COTININE-D3 DIBROMOCOTININE, HYDROBROMIDE PERBROMIDE TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE S-(-)-COTININE PERCHLORATE N-(4-METHOXYBENZYL)COTININE-PYRIDYL-D4 TRANS-3'-HYDROXYCOTININE-O-D-GLUCURONIDE, METHYL-D3 trans-3'-Hydroxycotinine-N-b-D-glucuronide (3S,5S)-3'-Hydroxycotinine