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(-)-COTININE

(-)-COTININE Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 400-666-7788 +86-10-82848833
Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:S-(-)-Cotinine, 98%
CAS:486-56-6
Purity:98% Package:1G;250MG
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:(-)-Cotinine;(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
CAS:486-56-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Alfa Aesar  
Tel: 400-610-6006; 021-67582000
Email: saleschina@alfa-asia.com
Products Intro: Product Name:(-)-Cotinine, 98%
CAS:486-56-6
Package:250Mg Remarks:L11873
Company Name: Energy Chemical  
Tel: 021-58432009 / 400-005-6266
Email: info@energy-chemical.com
Products Intro: Product Name:(-)-COTININE
CAS:486-56-6
Purity:98% Package:1g,250Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:S-(-)-Cotinine (1.0 Mg/ML in Methanol)
CAS:486-56-6
Purity:98%
(-)-COTININE Basic information
Product Name:(-)-COTININE
Synonyms:(S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone, S(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone;(5S)-1-Methyl-5-(3-pyridinyl)pyrrolidin-2-one;(5S)-1-Methyl-5-(3-pyridyl)pyrrolidin-2-one;Inchi=1/C10H12N2o/C1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/H2-3,6-7,9H,4-5H2,1h;()-Cotinine,(S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone, S()-1-Methyl-5-(3-pyridyl)-2-pyrrolidone;CREATINE ETHYL ESTER ANALYSIS KIT;L-COTININE;(5S)-(-)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one
CAS:486-56-6
MF:C10H12N2O
MW:176.22
EINECS:207-634-9
Product Categories:Metabolites;Nicotine Derivatives;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Inhibitors;Various Metabolites and Impurities
Mol File:486-56-6.mol
(-)-COTININE Structure
(-)-COTININE Chemical Properties
Melting point 40-42 °C(lit.)
Boiling point 250 °C150 mm Hg(lit.)
density 1.1102 (rough estimate)
refractive index 1.7110 (estimate)
Fp >230 °F
storage temp. 2-8°C
optical activity[α]/D -21±2°, c = 1 in ethanol
Water Solubility Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Merck 14,2553
BRN 83099
Stability:Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.
Safety Information
Hazard Codes Xn,Xi,T,F
Risk Statements 22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 7-16-36/37-45-36-26
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS GN1925500
10
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
(-)-COTININE Usage And Synthesis
Chemical PropertiesColourless to Light Brown Solid
UsesA major metabolite of nicotine in humans
UsesA major metabolite of Nicotine (N412450) in humans. Carcinogen.
Usesantidepressant
DefinitionChEBI: An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
Biological ActivityMajor metabolite of nicotine. Shown to activate a subpopulation of α 3/ α 6 β 2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo .
(-)-COTININE Preparation Products And Raw materials
Tag:(-)-COTININE(486-56-6) Related Product Information
(R,S) COTININE-N-B-D-GLUCURONIDE, METHYL-D3 COTININE-N-(4-DEOXY-4,5-DIDEHYDRO)-§-D-GLUCURONID DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3, 99 ATOM % D,(+/-)-COTININE-D3,COTININE-D3 (N-METHYL-D3) (-)-COTININE N-OXIDE ANTI-COTININE TRANS-3'-HYDROXYCOTININE-N-BETA-D-GLUCURONIDE, METHYL-D3 N-(4-METHOXYBENZYL)COTININE 1-(4-METHOXYBENZYL)-3-ACETOXYNORCOTININE COTININE-N-BETA-D-GLUCURONIDE,COTININE-N-ALPHA-D-GLUCURONIDE,COTININE-N-BETA-D-GLUCURONIDE, METHYL-D3,COTININE-N-B-D-GLUCURONIDE, METHYL-D3,COTININE-N-B-D-GLUCURONIDE,COTININE-N-A-D-GLUCURONIDE DL-Cotinine-methyl-D3,DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3,COTININE-D3 (N-METHYL-D3),(+/-)-COTININE-D3 DIBROMOCOTININE, HYDROBROMIDE PERBROMIDE TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE S-(-)-COTININE PERCHLORATE N-(4-METHOXYBENZYL)COTININE-PYRIDYL-D4 TRANS-3'-HYDROXYCOTININE-O-D-GLUCURONIDE, METHYL-D3 trans-3'-Hydroxycotinine-N-b-D-glucuronide (3S,5S)-3'-Hydroxycotinine TRANS-3'-HYDROXYCOTININE-2,3,4-TRI-O-ACETYL-O-BETA-D-GLUCURONIDE, METHYL ESTER