| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-GAD2
Purity:Prestige Antibodies P Package:100μL Remarks:HPA044637
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| | ANTI-GLUTAMATE DECARBOXYLASE, G65 Basic information |
| Product Name: | ANTI-GLUTAMATE DECARBOXYLASE, G65 | | Synonyms: | ANTI-GLUTAMATE DECARBOXYLASE, 65;ANTI-GLUTAMATE DECARBOXYLASE B10351, G65;ANTI-GLUTAMATE DECARBOXYLASE, G65;ANTI-GLUTAMATE DECARBOXYLASE (GAD65);ANTI-GLUTAMIC ACID DECARBOXYLASE 65;ANTI-GLUTAMIC ACID DECARBOXYLASE 65 (GAD65);ANTI-GAD 65;ANTI-GAD 65, 514-530 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-GLUTAMATE DECARBOXYLASE, G65 Structure]() |
| | ANTI-GLUTAMATE DECARBOXYLASE, G65 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-GLUTAMATE DECARBOXYLASE, G65 Usage And Synthesis |
| Uses | Anti-Glutamic Acid Decarboxylase 65 antibody produced in rabbit is suitable as a primary antibody for the determination of expression of GAD 65 isoform in putative P boutons in rat and mouse at a working dilution of 1:5000 and in lysates prepared from rat testis at different developmental ages and rat cerebellum by immunoblotting.
It is also suitable for immunohistochemistry at a working dilution of 1:500 using formalin-fixed, paraffin-embedded sections of rat pancreas and for microarray. | | General Description | GAD is predominantly expressed in the central nervous system (CNS) and pancreatic islets. It is also expressed in testis, oviduct and ovary. GAD exists in two isofoms, GAD 65 and GAD 67. GAD65 is targeted to membranes and nerve endings. | | Biochem/physiol Actions | Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L-glutamate to γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. It has been identified as an autoantigen in insulin-dependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS) and may serve as a marker in the early stages of IDDM. GAD 65 synthesizes transmitter GABA for vesicular release. |
| | ANTI-GLUTAMATE DECARBOXYLASE, G65 Preparation Products And Raw materials |
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