| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
SIGMA-RBI |
| Tel: |
800 736 3690 (Orders) |
| Email: |
|
|
| | ANTI-GFI-1 Basic information |
| Product Name: | ANTI-GFI-1 | | Synonyms: | Anti-GFI1 (AB1) antibody produced in rabbit;Anti-GFI1 (AB2) antibody produced in rabbit;Monoclonal Anti-Growth Factor Independence-1 antibody produced in mouse;ANTI-GFI-1;ANTI-HUMAN GFI-1;ANTI-ZNF163;MONOCLONAL ANTI-GROWTH FACTOR INDEPENDENCE-1;RABBIT ANTI-HUMAN GFI-1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-GFI-1 Structure]() |
| | ANTI-GFI-1 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | ANTI-GFI-1 Usage And Synthesis |
| Uses | Rabbit Anti-GFI1 (AB2) antibody can be used for western blot applications at a concentration of 1μg/ml. | | General Description | Gfi-1 is a zinc finger repressor that inhibits the proliferation and conserves functional integrity of hematopoietic stem cells. Human GFI1 mutations have been linked to neutropenia.
Rabbit Anti-GFI1 (AB1) antibody recognizes human, mouse, rat, and canine GFI1. | | Biochem/physiol Actions | GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. |
| | ANTI-GFI-1 Preparation Products And Raw materials |
|