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Product Name:5-methyl thiopentyl isothiocyanate
CAS:4430-42-6
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| | BERTEROIN Basic information |
| Product Name: | BERTEROIN | | Synonyms: | 1-isothiocyanato-5-methylsulfanylpentane;1-isothiocyanato-5-methylsulfanyl-pentane;BERTEROIN;berteroin,1-isothiocyanato-5-(methylthio)-pentane,5-methylthiopentylisothiocyanate;1-isothiocyanato-5-(methylthio)pentane;Pentane, 1-isothiocyanato-5-(methylthio)-;KB47947;KB-47947 | | CAS: | 4430-42-6 | | MF: | C7H13NS2 | | MW: | 175.31 | | EINECS: | | | Product Categories: | | | Mol File: | 4430-42-6.mol |  |
| | BERTEROIN Chemical Properties |
| Melting point | 155～156℃ | | Boiling point | 155 °C(Press: 10 Torr) | | density | 1.01±0.1 g/cm3(Predicted) | | FEMA | 4416 | 5-(METHYLTHIO)PENTYL ISOTHIOCYANATE | | storage temp. | Store at -20°C | | solubility | DMF: 3 mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml | | Odor | at 0.01 % in propylene glycol. cabbage radish | | Odor Type | radish | | JECFA Number | 1896 | | LogP | 2.67 |
| | BERTEROIN Usage And Synthesis |
| Description | Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. At 1.7 μM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells. Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity. It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt. | | Chemical Properties | Pale yellow liquid; penetrating radish-like aroma | | Occurrence | Reported found in radish and horseradish. | | Uses | Berteroin is a compound with high odor potency occurring in horseradish ( Armoracia rusticana) | | Definition | ChEBI: Berteroin is an isothiocyanate. | | Aroma threshold values | High strength odor; recommend smelling in a 0.01% solution or less. | | Enzyme inhibitor | This sulforaphane analogue and antimetastatic agent (FW = 175.43 g/mol; CAS 4430-42-6; Physical State = Liquid; Soluble in ethanol, DMSO, and chloroform; Store at -20° C; M.P. = 155-156° C), also named 5- methylthiopentyl isothiocyanate, is found in cruciferous vegetables (including Chinese cabbage and rucola leaves) and mustard oil. Berteroin inhibits LPS-induced degradation of Inhibitor of κBα (or IκBα) as well as NF-κB p65 translocation into the nucleus and DNA binding. Berteroin also suppresses degradation of IL-1 Receptor Associated Kinase and phosphorylation of Transforming Growth Factor β-Activated Kinase-1. Berteroin also inhibits LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT |
| | BERTEROIN Preparation Products And Raw materials |
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