| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:MDM2-p53-IN-1b
CAS:856435-40-0
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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| Company Name: |
Interbioscreen Ltd.
|
| Tel: |
+7 (49) 6524-0091 |
| Email: |
screen@ibscreen.chg.ru |
| Products Intro: |
CAS:856435-40-0
Purity:95% Package:1mg Remarks:C17H15NO3
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(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one manufacturers
- MDM2-p53-IN-1b
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- $2500.00 / 100mg
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2025-08-21
- CAS:856435-40-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Basic information |
| Product Name: | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one | | Synonyms: | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one;MDM2 p53 IN 1b;MDM2-p53 inhibitor 1b;MDM2p53IN1b;MDM2-p53-IN-1b;MDM-2-p53-IN-1b,MDM2p53IN1b;2H-Indol-2-one, 3-[(2,4-dimethoxyphenyl)methylene]-1,3-dihydro-, (3E)-;Antiproliferative agent-62 | | CAS: | 856435-40-0 | | MF: | C17H15NO3 | | MW: | 281.31 | | EINECS: | | | Product Categories: | | | Mol File: | 856435-40-0.mol | ![(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Structure](CAS/20180723/GIF/856435-40-0.gif) |
| | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Chemical Properties |
| Melting point | 210-211 °C | | Boiling point | 518.7±50.0 °C(Predicted) | | density | 1.240±0.06 g/cm3(Predicted) | | pka | 12.74±0.20(Predicted) |
| | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Usage And Synthesis |
| Description | MDM2-p53-IN-1b is an inhibitor of the MDM2-p53 interaction. | | Uses | Antiproliferative agent-62 is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116. | | References | [1] Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity |
| | (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Preparation Products And Raw materials |
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