| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Carboxylesterase 1 isoform b human
CAS:9013-79-0
Purity:recombinant, expressed in baculovirus infected BTI insect ce Package:1VL Remarks:E0287-1VL
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
CAS:9013-79-0
Remarks:recombinant, expressed in baculovirus infected BTI insect cells
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| | EC 3.1.1.1 Basic information |
| Product Name: | EC 3.1.1.1 | | Synonyms: | LIPASE CA;Carboxylesterase 1 isoform b human;Carboxylesterase 1 human;Carboxylesterase 1 isoform c human;CARBOXYLESTERASE, IMMOBILIZED;CARBOXYLIC-ESTER HYDROLASE;CARBOXYL ESTERASE;EC 3.1.1.1 | | CAS: | 9013-79-0 | | MF: | | | MW: | 0 | | EINECS: | 232-773-7 | | Product Categories: | | | Mol File: | Mol File | ![EC 3.1.1.1 Structure]() |
| | EC 3.1.1.1 Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | slightly brown |
| | EC 3.1.1.1 Usage And Synthesis |
| Uses | Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner. It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ. | | Uses | Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies. | | General Description | Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. | | Biochem/physiol Actions | Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs. |
| | EC 3.1.1.1 Preparation Products And Raw materials |
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