- Iodixanol
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- $0.00 / 25KG
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2023-08-29
- CAS:92339-11-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- Iodixanol
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- $0.00 / 1g
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2023-08-18
- CAS:92339-11-2
- Min. Order: 1g
- Purity: 0.99
- Supply Ability: 100kg
- Iodixanol
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- $30.00 / 1KG
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2023-08-16
- CAS:92339-11-2
- Min. Order: 1KG
- Purity: >99%
- Supply Ability: 20tons
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| | Iodixanol Basic information |
| Product Name: | Iodixanol | | Synonyms: | Acupaque;DU-6807;Iodixanol (200 mg);5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetyliMino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-;odixanol;IODIXANOL;1,3-benzenedicarboxamide,5,5’-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis;n’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-( | | CAS: | 92339-11-2 | | MF: | C35H44I6N6O15 | | MW: | 1550.18 | | EINECS: | 618-837-0 | | Product Categories: | Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals;92339-11-2 | | Mol File: | 92339-11-2.mol |  |
| | Iodixanol Chemical Properties |
| Melting point | 262-267°C (dec.) | | Boiling point | 1250.9±65.0 °C(Predicted) | | density | 1.266 ±0.003 | | vapor pressure | 0Pa at 20℃ | | refractive index | n 1.4128 ±0.0003 | | storage temp. | Refrigerator | | solubility | Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride. | | pka | 11.04±0.46(Predicted) | | color | White | | LogP | 0.7 | | EPA Substance Registry System | 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2) |
| | Iodixanol Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | OptiPrep,Nycomed Pharma,Norway | | Uses | Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium). | | Definition | ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography. | | Manufacturing Process | Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was
cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with
methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended
in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal
(0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one
day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2
(42.5 ml) was added through a dropping funnel over 1 hour. The solution was
heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g)
was suspended in acetic anhydride (480 ml) and heated to 50°C.
Concentrated sulfuric acid (3 ml) was then added. The starting material was
dissolved after a few minutes, and the reaction mixture was heated at 60°C
for 75 min. After cooling the residue dissolved in methanol (300 ml) with
water (150 ml) the solution was heated to 50°C and the pH adjusted to about
10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and
the hydrolysis was complete. The reaction mixture was cooled to 20°C and
neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido-
2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and
washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the
reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-
triiodoisophtalamide (304 g) was added after two hours of stirring. All solids
were allowed to dissolve overnight before cooling to 30°C and adjustment to
pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the
solution after further cooling to 15°C, and the reaction was allowed to proceed
for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-
dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was
obtained. | | Brand name | Visipaque (GE Healthcare). | | Therapeutic Function | Diagnostic aid | | General Description | Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures. |
| | Iodixanol Preparation Products And Raw materials |
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