| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Protectin D1
CAS:660430-03-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Protectin D1
CAS:660430-03-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
amyjetsci
|
| Tel: |
027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
| Products Intro: |
Product Name:Protectin D1
Package:1EA/
|
| Company Name: |
Beijing Biocreative Technology Co., Ltd.
|
| Tel: |
15522676233 |
| Email: |
3007606172@qq.com |
| Products Intro: |
Product Name:NPD1
CAS:660430-03-5
Purity:99% HPLC Package:10.0?μg; 25.0?μg; 50.0?μg; 100.0?μg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Protectin D1;Protectin D-1,Protectin D1
CAS:660430-03-5
Purity:98% Package:5 mg
|
|
| | Protectin D1 Basic information |
| Product Name: | Protectin D1 | | Synonyms: | Protectin D1;4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-;NPD1;Protectin D-1,Protectin D1 | | CAS: | 660430-03-5 | | MF: | C22H32O4 | | MW: | 360.49 | | EINECS: | | | Product Categories: | | | Mol File: | 660430-03-5.mol |  |
| | Protectin D1 Chemical Properties |
| Boiling point | 559.4±50.0 °C(Predicted) | | density | 1.048±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.1 mg/ml | | pka | 4.58±0.10(Predicted) |
| | Protectin D1 Usage And Synthesis |
| Description | Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 μg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF. | | Uses | Protectin D1 is a potent anti-inflammatory lipid mediator. | | Definition | ChEBI: Protectin D1 is a dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 It has a role as an anti-inflammatory agent, a neuroprotective agent, a PPARgamma agonist, an apoptosis inhibitor, a hepatoprotective agent, a human xenobiotic metabolite and a specialised pro-resolving mediator. It is a dihydroxydocosahexaenoic acid, a secondary allylic alcohol and a protectin. |
| | Protectin D1 Preparation Products And Raw materials |
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