1370046-40-4
中文名称 | 1370046-40-4 |
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中文同义词 | 3-苯基-5-(3,4,5-三甲氧基苯基)-4,5-二氢-1H-吡唑-1-硫代酰胺;SSE15206游离;化合物SSE15206 |
英文名称 | SSE15206 |
英文同义词 | SSE15206;SSE-15206;SSE 15206;SSE15206; SSE-15206; SSE 15206;1370046-40-4;1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-;4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide;3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide;Inhibitor,Apoptosis,Microtubule/Tubulin,inhibit,SSE 15206,SSE-15206,SSE15206;5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide |
CAS号 | 1370046-40-4 |
分子式 | C19H21N3O3S |
分子量 | 371.45 |
EINECS号 | |
相关类别 | API |
Mol文件 | 1370046-40-4.mol |
结构式 |
1370046-40-4 性质
沸点 | 518.7±60.0 °C(Predicted) |
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密度 | 1.27±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:112.0(最大浓度 mg/mL);301.52(最大浓度 mM) |
酸度系数(pKa) | 14.12±0.60(Predicted) |
GI50: 197 nM (microtubule).
SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI 50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines.
Western Blot Analysis
Cell Line: | Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. |
Concentration: | 5 × and 10 × GI 50 values (GI 50 =197 nM in HCT-116 cells). |
Incubation Time: | 24 hours. |
Result: | Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-111425 | 1370046-40-4 SSE15206 | 1370046-40-4 | 5mg | 690元 |
2024/01/25 | HY-111425 | 1370046-40-4 SSE15206 | 1370046-40-4 | 10mM * 1mLin DMSO | 759元 |