| Company Name: |
BOC Sciences
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info@bocsci.com |
| Products Intro: |
Product Name:EMD 66684
CAS:1216884-39-7
Purity:≥98% by HPLC Remarks:EMD 66684 is a potent and selective non-peptide angiotensin AT1 receptor antagonist (IC50 = 0.7 and > 10000 nM for AT1 and AT2 receptors, respectively). It inhibits isolated rabbit aorta contractions
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581 |
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sales@chemhifuture.com |
| Products Intro: |
Product Name:EMD 66684
CAS:1216884-39-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:EMD 66684
CAS:1216884-39-7
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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EMD 66684 manufacturers
- EMD 66684
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- $2500.00 / 100mg
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2025-10-27
- CAS:1216884-39-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | EMD 66684 Basic information |
| Product Name: | EMD 66684 | | Synonyms: | 2-Butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl-4-yl]methyl]-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride | | CAS: | 1216884-39-7 | | MF: | C28H31ClN8O2 | | MW: | 547.06 | | EINECS: | | | Product Categories: | | | Mol File: | 1216884-39-7.mol |  |
| | EMD 66684 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | <27.35mg/ml in DMSO; <27.35mg/ml in ethanol |
| | EMD 66684 Usage And Synthesis |
| Uses | EMD 66684 is a useful intermediate. | | in vivo | EMD 66684 (0.1, 0.3, 1 mg/kg; i.v.; once) results in a long lasting fall in blood pressure[3].
EMD 66684 (0.1 μM; 45 min) decreases the NS-induced overflow of NE and NPY from preparations from SHRs at 10-12 weeks old[4]. | Animal Model: | Conscious furosemide-treated SHR (Spontaneous Hypertension Rat)[3] | | Dosage: | 0.1, 0.3, 1 mg/kg | | Administration: | Intravenous injection; once; as potassium salts to conscious furosemide-treated SHR | | Result: | Showed a long lasting fall in blood pressure, resulted mean arterial pressure (MAP) decreased in a dose-dependent manner.
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| | IC 50 | Angiotensin II Type 1: 0.7 nM (IC50) |
| | EMD 66684 Preparation Products And Raw materials |
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