| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:BRD2 Inhibitor II, BIC1 - Calbiochem
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Product Name:BRD2 Inhibitor II, BIC1 - Calbiochem
|
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| | BRD2 Inhibitor II, BIC1 - Calbiochem Basic information |
| | BRD2 Inhibitor II, BIC1 - Calbiochem Chemical Properties |
| | BRD2 Inhibitor II, BIC1 - Calbiochem Usage And Synthesis |
| General Description | A cell-permeable benzimidazolyl-benzimidazolothione that targets the BD1 domain of the BET family member BRD2 (Kd = 28 μM), making it inaccessible for acetylated H4K12 (histone H4 Lys12) binding. Shown to effectively inhibit TSA- (Cat. No. 647925; 1 h 1 μM) induced BRD2 BD1-H4K12 association in COS7 cells (100% inhibition by 60 μM BIC1) and greatly suppress active Ras-induced SV40 promoter transcription activity in HeLa cells (70% inhibition by 5 μM BIC1), while being much less effective against BRDT BD1 binding to acetylated H4K5/K8. |
| | BRD2 Inhibitor II, BIC1 - Calbiochem Preparation Products And Raw materials |
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