| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
| Products Intro: |
Product Name:BAY-826
CAS:1448316-08-2
Purity:98% HPLC Package:1mg Remarks:V4169
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| | BAY-826
(BAY826) Basic information |
| Product Name: | BAY-826
(BAY826) | | Synonyms: | BAY-826
(BAY826);[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur;Sulfur, [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluoro-, (OC-6-21)- | | CAS: | 1448316-08-2 | | MF: | C26H19F5N6OS | | MW: | 558.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1448316-08-2.mol |  |
| | BAY-826
(BAY826) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12.49±0.70(Predicted) |
| | BAY-826
(BAY826) Usage And Synthesis |
| Description | BAY-826 is a highly potent, orally available TIE-2-inhibitor which improves tumor control in syngeneic mouse glioma models. | | Definition | ChEBI: BAY-826 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 3-cyano-5-(pentafluoro-lambda(6)-sulfanyl)benzoic acid with the amino group of 2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline. It is a potent TIE-2 inhibitor (Kd = 1.6 nM) which displays in vivo efficacy in some murine glioma models. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an antineoplastic agent. It is a member of pyridines, an imidazopyrazole, a member of benzamides, a secondary carboxamide, a nitrile, an organofluorine compound and an organosulfur compound. | | storage | Store at -20°C |
| | BAY-826
(BAY826) Preparation Products And Raw materials |
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