NSC 23766 TETRAHYDROCHLORIDE

NSC 23766 TETRAHYDROCHLORIDE Suppliers list
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:NSC 23766
CAS:733767-34-5
Purity:98% Package:5mg Remarks:V1561
Company Name: Coresyn Pharmatech Co., Ltd.
Tel: +86-571-86626709 +86-18157142896
Email: cbc@coresyn.com
Products Intro: Product Name:N6-(2-((5-(diethylamino)pentan-2-yl)amino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
CAS:733767-34-5
Purity:NLT 98% Package:1G;1KG;100KG Remarks:CM30931
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:NSC 23766
CAS:733767-34-5
Purity:0.97 Package:mgs,gs,kgs Remarks:A909716
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:NSC 23766;N6-[2-[[4-(DiethylaMino)-1-Methylbutyl]aMino]-6-Methyl-4-pyriMidinyl]-2-Methyl-4,6-quinolinediaMinetrihydrochloride
CAS:733767-34-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: VDM Biochemicals   
Tel: 0330-2528181
Email: sales@vdmbio.com
Products Intro: Product Name:NSC 23766
CAS:733767-34-5
Purity:95%
NSC 23766 TETRAHYDROCHLORIDE Basic information
Product Name:NSC 23766 TETRAHYDROCHLORIDE
Synonyms:NSC 23766 TETRAHYDROCHLORIDE;N6-[2-[[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO]-6-METHYL-4-PYRIMIDINYL]-2-METHYL-4,6-QUINOLINEDIAMINE TRIHYDROCHLORIDE;NSC 23766;N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride;N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine;NSC23766;NSC 23766;CS-1187;CS-594
CAS:733767-34-5
MF:C24H35N7
MW:421.58
EINECS:
Product Categories:Rac1 Inhibitor.;G-Protein;Other enzyme inhibitors and activators
Mol File:733767-34-5.mol
NSC 23766 TETRAHYDROCHLORIDE Structure
NSC 23766 TETRAHYDROCHLORIDE Chemical Properties
storage temp. Desiccate at RT
solubility Soluble in DMSO (50 mg/ml); Water (50 mg/ml)
form White powder solid.
color White
Water Solubility Soluble in water.
Sensitive Light Sensitive & Hygroscopic
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Safety Information
MSDS Information
NSC 23766 TETRAHYDROCHLORIDE Usage And Synthesis
DescriptionNSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
UsesThe compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.
DefinitionChEBI: NSC 23766 is an aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1). It has a role as an EC 3.6.5.2 (small monomeric GTPase) inhibitor, an antiviral agent, a muscarinic antagonist and an apoptosis inducer. It is an aminoquinoline, an aminopyrimidine, a primary amino compound, a secondary amino compound and a tertiary amino compound.
Biological ActivitySelective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC 50 ~ 50 μ M) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and reported to reverse tumor cell phenotyes in prostate cancer cells.
ReferencesGao et al. (2004), Rational design and characterization of a Rac GTPase-specific small molecule inhibitor; Proc. Natl. Acad. Sci. USA, 101 7618 Shankar et al. (2013), Raft endocytosis of AMF regulates mitochondrial dynamics through Rac1 signaling and the Gp78 ubiquitin ligase; J. Cell Sci., 126 3295 Levay et al. (2013), NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors; J. Pharmacol. Exp. Ther., 347 69
NSC 23766 TETRAHYDROCHLORIDE Preparation Products And Raw materials
Tag:NSC 23766 TETRAHYDROCHLORIDE(733767-34-5) Related Product Information
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