RS 102895 manufacturers
- RS 102895
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- $0.00 / 1kg
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2022-09-08
- CAS:300815-41-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| | RS 102895 Basic information |
| Product Name: | RS 102895 | | Synonyms: | 1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;RS 102895 HYDROCHLORIDE;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895 | | CAS: | 300815-41-2 | | MF: | C21H21F3N2O2 | | MW: | 390.4 | | EINECS: | | | Product Categories: | RS 102895 CCR2-selective chemokine receptor antagonist.;Cytokine signaling | | Mol File: | 300815-41-2.mol |  |
| | RS 102895 Chemical Properties |
| Boiling point | 446.1±45.0 °C(Predicted) | | density | 1.33±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | Desiccate at RT | | solubility | DMSO: 18 mg/mL, clear, colorless | | form | powder | | pka | 13.46±0.20(Predicted) | | color | white |
| | RS 102895 Usage And Synthesis |
| Uses | RS 102895 is a CCR2-selective chemokine receptor inhibitor. | | Biological Activity | CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors. |
| | RS 102895 Preparation Products And Raw materials |
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