| Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312 |
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liming@bio-fount.com |
| Products Intro: |
Product Name:1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)-
CAS:1679333-73-3
Purity:97.0% Package:5mg
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1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- manufacturers
- MMV008138
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- $446.00 / 5mg
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2024-10-28
- CAS:1679333-73-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- Basic information |
| Product Name: | 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- | | Synonyms: | MMV008138;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)-;MMV008138,MMV-008138 | | CAS: | 1679333-73-3 | | MF: | C18H14Cl2N2O2 | | MW: | 361.22 | | EINECS: | | | Product Categories: | | | Mol File: | 1679333-73-3.mol | ![1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- Structure](CAS/20200401/GIF/1679333-73-3.gif) |
| | 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- Chemical Properties |
| Boiling point | 577.9±50.0 °C(Predicted) | | density | 1.473±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (346.05 mM) | | form | Solid | | pka | 2.09±0.40(Predicted) | | color | Light yellow to yellow |
| | 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- Usage And Synthesis |
| Uses | MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM[1][2]. | | IC 50 | Plasmodium | | References | [1] Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. DOI:10.1021/acsinfecdis.7b00159
[2] Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9. DOI:10.1016/j.bmcl.2015.02.020 |
| | 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- Preparation Products And Raw materials |
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