GNE-0439 manufacturers
- GNE-0439
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- $2500.00 / 100mg
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2025-11-05
- CAS:1241902-40-8
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
- GNE-0439
-
- $2500.00 / 100mg
-
2025-08-28
- CAS:1241902-40-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | GNE-0439 Basic information |
| Product Name: | GNE-0439 | | Synonyms: | GNE0439;GNE-0439;GNE0439,GNE 0439;L-Valine, N-[4-(4-propylcyclohexyl)benzoyl]- | | CAS: | 1241902-40-8 | | MF: | C21H31NO3 | | MW: | 345.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1241902-40-8.mol |  |
| | GNE-0439 Chemical Properties |
| Boiling point | 529.9±43.0 °C(Predicted) | | density | 1.058±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 200 mg/mL (578.90 mM; Need ultrasonic) | | pka | 3.78±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | GNE-0439 Usage And Synthesis |
| Uses | GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1]. | | References | [1] Chernov-Rogan T, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. DOI:10.1073/pnas.1713701115 |
| | GNE-0439 Preparation Products And Raw materials |
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