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Guanidine hydrochloride

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Company Name: Henan DaKen Chemical CO.,LTD.
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Purity:99.00% Package:100g,500g,1KG,10KG,100KG
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Tel: 0371-55170693
Products Intro: Product Name:50-01-1
Purity:0.99 Package:25KG,5KG;1KG;500G

Lastest Price from Guanidine hydrochloride manufacturers

  • Guanidine HCl solution
  • US $20.00 / KG
  • 2020-08-19
  • CAS: 50-01-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 30 Ton/Tons per Month
Guanidine hydrochloride Basic information
description Protein Denaturation Uses Drug intermediates Preparation Reference quality standards References
Product Name:Guanidine hydrochloride
Synonyms:guanidine,monohydrochloride;guanidinechloride;Guanidinemonohydrochloride;guanidiniumhydrochloride;AMINOFORMAMIDINE HCL;AMINOFORMAMIDINE HYDROCHLORIDE;AMINOMETHANAMIDINE HCL;AMINOMETHANAMIDINE HYDROCHLORIDE
Product Categories:Disinfectants;Test Reagents;Miscellaneous Biochemicals;Pharmaceutical Intermediates;PP;Inhibitors;proteinmod
Mol File:50-01-1.mol
Guanidine hydrochloride Structure
Guanidine hydrochloride Chemical Properties
Melting point 180-185 °C(lit.)
density 1.18 g/mL at 25 °C(lit.)
refractive index n20/D 1.465
storage temp. Store at RT.
solubility H2O: 6 M, clear, colorless
form Crystals
color White to slightly yellow
PH4.5-5.5 (100g/l, H2O, 20℃)
PH Range4.5 - 6.0 at 573 g/l at 25 °C
Water Solubility 2280 g/L (20 ºC)
λmaxλ: 260 nm Amax: 0.040
λ: 280 nm Amax: 0.025
Sensitive Hygroscopic
Merck 14,4562
BRN 3591990
Stability:Stable. Hygroscopic. Incompatible with strong oxidizing agents.
CAS DataBase Reference50-01-1(CAS DataBase Reference)
EPA Substance Registry SystemGuanidine monohydrochloride (50-01-1)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/38
Safety Statements 26-36-22
WGK Germany 1
RTECS MF4300000
HS Code 29252000
ToxicityLD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg
MSDS Information
Guanidine hydrochloride English
ACROS English
SigmaAldrich English
ALFA English
Guanidine hydrochloride Usage And Synthesis
descriptionGuanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Guanidine Hydrochloride is the hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Guanidine Hydrochloride is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine Hydrochloride is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins and isolation of RNA. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies. When utilized at lower concentrations, Guanidine Hydrochloride is noted to be useful in prompting the refolding of denatured proteins. Guanidine Hydrochloride is also been reported to allow return of enzymatic activity in protocols using Guanidine Hydrochloride as a first step. Guanidine Hydrochloride is an inhibitor of RNase.
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2-amino-6-methyl-pyrimidine and 2-amino-4,6-dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Protein DenaturationGuanidine Hydrochloride (GdnHCl) is a better denaturant than urea.It should normally give higher and lower values for m and for Cm, respectively, but identical deltaG° values. Since m values in both denaturants can be predicted/estimated from the size of the protein (Myers et al., 1995) and delatG° should not change, yes it is possible-in principle-to predict Cm in one denaturant, knowing its value in the other.
but to have a general correlation co-efficient is almost impossible as every protein has unique folding. Though such co-relation may be found for a special protein fold, but what purpose it may serve apart from giving a tentative idea that GdnHCl or urea may be a better denaturant! If you are looking for even better denaturant than Gdn HCl then use GdnSCN, it is better and more effective
UsesGuanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Drug intermediatesGuanidine hydrochloride drug used primarily as an intermediate in the manufacture of sulfadiazine, an important raw material sulfamethyldiazine, sulfamethazine and folic acid.
Guanidine hydrochloride (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4-diamino-6-hydroxy pyrimidine, folic acid for the synthesis of antianemic. Furthermore guanidine hydrochloride also used synthetic anti-static agent.
PreparationIn Dicyanodiamide and ammonium (Ammonium chloride) as raw material, melt reaction at 170-230 ℃, guanidine hydrochloride obtained crude, refined products.
Reference quality standardsName of Project Specifications
Pharmaceutical grade industrial grade
Appearance white crystal; white crystal
Content > 99% 99.5%
Ammonium <0.3% 0.5%
Water Insoluble substance <0.1% 0.1%
Moisture <0.3% 0.3%
Ash <0.05% 0.05%
Water-soluble test qualified; qualified
Melting range °C 184-188; 182-188
Absorbance (UV wavelength 260NM) <=0.04
Absorbance (UV wavelength 280NM) <=0.02
PH value (4% aqueous solution) 6.4 ± 0.2 6.4 ± 0.2
Chemical PropertiesWhite cryst. powder
UsesGuanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant.
UsesUsed to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.
DefinitionChEBI: An aminocarboxamidine, the parent compound of the guanidines.
HazardToxic by ingestion, evolves hydrogen chloride fumes on heating.
Purification MethodsCrystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.]
Tag:Guanidine hydrochloride(50-01-1) Related Product Information
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