薁磺酸钠
| 中文名称 | 薁磺酸钠 |
|---|---|
| 中文同义词 | 愈创木薁磺酸钠;薁磺酸钠;7-异丙基-1,4-二甲基甘菊环-3-磺酸钠;7-异丙基-1,4-二甲基甘菊蓝-3-磺酸钠盐;磺酸钠;奥磺酸钠;呱仑酸钠;1,4-二甲基-7-异丙基甘菊环-3-磺酸钠 |
| 英文名称 | Sodium gualenate |
| 英文同义词 | 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULFONATE SODIUM SALT;sodium gualenate;Sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate;Azulene sulfonate sodium;3-Sulfonate sodium salt;Sodium 7-Isopropyl-1,4-dimethylazulene-3-sulfonate;Sodium 5-isopropyl-3,8-dimethylazulene-1-sulfonate;sodium,3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate |
| CAS号 | 6223-35-4 |
| 分子式 | C15H17NaO3S |
| 分子量 | 300.35 |
| EINECS号 | 228-309-8 |
| 相关类别 | 烯烃;医药 消毒剂;医药消毒剂;呱仑酸钠;愈创木薁磺酸钠;API;薁磺酸钠;原料;原料药;医药原料;其他化工产品;医药原料中间体;日用化学品;植物提取物;化学试剂 |
| Mol文件 | 6223-35-4.mol |
| 结构式 |  |
薁磺酸钠 性质
| 熔点 | 98°C(lit.) |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 二甲基亚砜：30 mg/mL（99.88 mM） |
| 形态 | 粉末至结晶 |
| 颜色 | 蓝色至深蓝色 |
| Merck | 14,4554 |
薁磺酸钠不稳定，受光照，空气氧化和高温环境下会分解，易脱去磺酸基。根据现有报道，薁磺酸钠含有半个或一个结晶水均是常见情况。
薁磺酸钠是洋甘菊花的有效成分，具有很强的抗胃蛋白酶、消炎、抗菌、抗过敏、促进粘膜新城代谢的作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。
薁磺酸钠通过局部直接作用抑制炎性细胞释放组胺；增加粘膜内前列腺素E2的合成，促进肉芽形成和上皮细胞新生；并能降低胃蛋白酶的活性。Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物，具有优良的抗炎和愈伤作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP.
Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown.
安全信息
| RTECS号 | CO4826000 |
|---|---|
| 海关编码 | 2908.99.1500 |