盐酸丙咪嗪
中文名称 | 盐酸丙咪嗪 |
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中文同义词 | 盐酸丙咪嗪溶液, 100PPM;N,N-二甲基-10,11-二氢-5H-二苯并[b,f]氮杂卓-5-丙胺盐酸盐;盐酸丙咪嗪;托弗尼尔;丙咪嗪盐酸;丙咪嗪盐酸盐;丙咪嗪;咪帕明 |
英文名称 | Imipramine hydrochloride |
英文同义词 | Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;Imipramine Hydrochloride (200 mg);Methanol(test Imipramine HCl, 1.0 mg/mL as free base);10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine;5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride;tofranil;tofranile;LABOTEST-BB LT00452014 |
CAS号 | 113-52-0 |
分子式 | C19H25ClN2 |
分子量 | 316.87 |
EINECS号 | 204-030-7 |
相关类别 | 药物成分 (研究实验用);医药原料;医药原料药;原料药及中间体;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Adrenoceptor;API |
Mol文件 | 113-52-0.mol |
结构式 |
盐酸丙咪嗪 性质
熔点 | 168-1700C |
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闪点 | 9℃ |
储存条件 | 2-8°C |
溶解度 | H2O:50 mg/mL |
形态 | 结晶 |
颜色 | 白色 |
PH值 | 4.2~5.2(100g/l,25℃) |
水溶解性 | Soluble in water |
最大波长(λmax) | 260nm(lit.) |
Merck | 14,4920 |
CAS 数据库 | 113-52-0(CAS DataBase Reference) |
EPA化学物质信息 | 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0) |
IC50: 32 nM (serotonin)
Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter.
Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor.
安全信息
危险品标志 | Xn,T,F |
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危险类别码 | 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11 |
安全说明 | 7-16-24-33-45-36-26-36/37 |
危险品运输编号 | UN 1230 3/PG 2 |
WGK Germany | 3 |
RTECS号 | HO1925000 |
TSCA | Yes |
海关编码 | 2933995800 |
毒性 | LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe) |
提供商 | 语言 |
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英文
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