盐酸丙咪嗪

盐酸丙咪嗪

中文名称盐酸丙咪嗪
中文同义词盐酸丙咪嗪溶液, 100PPM;N,N-二甲基-10,11-二氢-5H-二苯并[b,f]氮杂卓-5-丙胺盐酸盐;盐酸丙咪嗪;托弗尼尔;丙咪嗪盐酸;丙咪嗪盐酸盐;丙咪嗪;咪帕明
英文名称Imipramine hydrochloride
英文同义词Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;Imipramine Hydrochloride (200 mg);Methanol(test Imipramine HCl, 1.0 mg/mL as free base);10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine;5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride;tofranil;tofranile;LABOTEST-BB LT00452014
CAS号113-52-0
分子式C19H25ClN2
分子量316.87
EINECS号204-030-7
相关类别药物成分 (研究实验用);医药原料;医药原料药;原料药及中间体;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Adrenoceptor;API
Mol文件113-52-0.mol
结构式盐酸丙咪嗪 结构式

盐酸丙咪嗪 性质

熔点168-1700C
闪点9℃
储存条件2-8°C
溶解度H2O:50 mg/mL
形态结晶
颜色白色
PH值4.2~5.2(100g/l,25℃)
水溶解性Soluble in water
最大波长(λmax)260nm(lit.)
Merck14,4920
CAS 数据库113-52-0(CAS DataBase Reference)
EPA化学物质信息5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0)

盐酸丙咪嗪 用途与合成方法

Imipramine hydrochloride 抑制血清素转运蛋白(serotonin),IC50 值为 32 nM。Imipramine hydrochloride 可阻止胰酶的易位,抑制 MV 和外泌体的分泌。

IC50: 32 nM (serotonin)

Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter.

Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor.

化学性质 
白色结晶性粉末。熔点174-175℃。易溶于水、乙醇,微溶于丙酮,几乎不溶于乙醚。无臭,味苦。遇光渐变色。米帕明碱([50-49-7])沸点160℃(13.3Pa)。
用途 
镇静安眠性抗组织胺及抗抑郁药,治疗精神抑郁症及小儿遗尿症。
用途 
用于治疗各种类型抑郁症、小儿遗尿症等
生产方法 
10,11-二氢-5-二苯并[b,f]氮杂卓(见14230)与甲苯、钠氨一起加热回流1h,冷至40-50℃,滴加1-氯-3-二甲氨基丙烷,再回流16h。冷却,过滤,滤液水洗层,取甲苯层减压蒸馏,回收甲苯后,收集210-230℃(0.67kPa)馏分,得米帕明碱,最后经成盐而得成品。

安全信息

危险品标志Xn,T,F
危险类别码23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11
安全说明7-16-24-33-45-36-26-36/37
危险品运输编号UN 1230 3/PG 2
WGK Germany3
RTECS号HO1925000
TSCAYes
海关编码2933995800
毒性LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B1490盐酸丙咪嗪
Imipramine hydrochloride
113-52-0100mg500元
2024/01/25HY-B1490盐酸丙咪嗪
Imipramine hydrochloride
113-52-010mM * 1mLin DMSO550元

盐酸丙咪嗪 上下游产品信息

"盐酸丙咪嗪"相关产品信息
盐酸西替利嗪 盐酸苯海拉明 N,N-二甲基-1,3-二氨基丙烷 盐酸拓扑替康 米帕明 1-金刚烷乙胺 异丙胺 丁酸丙酯 异丙醇 没食子酸丙酯 曲米帕明 盐酸丙酰丙嗪 脱氧麻黄碱 盐酸左氧氟沙星片 盐酸西布曲明 盐酸小檗碱片 盐酸曲马多 安非他明 丙咪嗪
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