- Dynorphin A (1-13)
-
- $0.00 / 1g
-
2024-09-18
- CAS:72957-38-1
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 1000g
- Dynorphin A (1-13)
-
- $75.00 / 1kg
-
2024-08-27
- CAS:72957-38-1
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
- Dynorphin A (1-13)
-
- $0.00 / 1Gram
-
2024-08-26
- CAS:72957-38-1
- Min. Order: 1Gram
- Purity: 99%, USP, EP
- Supply Ability: 100KG
|
| Dynorphin A (1-13) Basic information |
| Dynorphin A (1-13) Chemical Properties |
density | 1.39±0.1 g/cm3(Predicted) | RTECS | JV7436666 | storage temp. | Inert atmosphere,Store in freezer, under -20°C | form | Solid | pka | 3.31±0.10(Predicted) | color | White to off-white | Water Solubility | Water: ≥ 60 mg/mL (37.41 mM) | Sequence | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH | InChIKey | OVVIBUHLQIYUEU-JASZZEBFNA-N |
WGK Germany | 3 | HS Code | 2933998090 |
| Dynorphin A (1-13) Usage And Synthesis |
Description | Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1]. | Application | Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS). | Biochem/physiol Actions | Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability. | References | [1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004. |
| Dynorphin A (1-13) Preparation Products And Raw materials |
|