| Company Name: |
Atlas antibodies |
| Tel: |
46-854595850 |
| Email: |
order@atlasantibodies.com |
| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
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ordercn@merckgroup.com |
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| | ANTI-NF KAPPA B P52 Basic information |
| Product Name: | ANTI-NF KAPPA B P52 | | Synonyms: | NF-KAPPAB (P52) (AB-1) POLYCLONAL ANTIBODY;Anti-NFKB2 antibody produced in rabbit;ANTI-NUCLEAR FACTOR KAPPAB (P52) (AB-1), HUMAN;ANTI-NUCLEAR FACTOR KAPPA-B (AB-1) RABBIT PAB;ANTI-NUCLEAR FACTOR KAPPAB;ANTI-NFKB2;ANTI-NF-KAPPAB (P52) (AB-1) RABBIT PAB;ANTI-NF-KAPPAB (P52) (AB-1), HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-NF KAPPA B P52 Structure]() |
| | ANTI-NF KAPPA B P52 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | ANTI-NF KAPPA B P52 Usage And Synthesis |
| Uses | research pathology | | Biological Activity | Nuclear factor NF-K-B p100 subunit (NFKB2) is at the endpoint of many of signal transduction pathways which are initiated by stimuli such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. It forms a homo- or heterodimeric complex with proteins. These complexes bind at K-B sites in the DNA of their target genes. NFKB2 complexes are present in the cytoplasm in an inactive state bound to the NF-K-B inhibitors. For the activation of NFKB2, I-K-B (inhibitor) is phosphorylated by I-K-B kinases (IKKs) and degraded. Thus the active NF-K-B complex is free from the inhibitor and can translocate to the nucleus. NFKB2 plays an important role in the cytoplasmic retention of attached NFKB2 proteins by p100 and the generation of p52 by cotranslational processing. It also regulates the circadian clock by repressing the transcriptional activator activity of the complex formed by aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) with other proteins. |
| | ANTI-NF KAPPA B P52 Preparation Products And Raw materials |
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