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ALL-TRANS-RETINAL Suppliers list
Tel: +86-021-61551611 +8615751773523
Products Intro: Product Name:All-trans-retinal
Purity:98% Package:Package as requetsed
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739
Products Intro: Product Name:trans-Retinal
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Wholesale price
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Products Intro: Product Name:ALL-TRANS-RETINAL
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Products Intro: Product Name:ALL-TRANS-RETINAL
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Products Intro: Product Name:all trans-Retinal
Purity:As coa Package:As request Remarks:116-31-4

ALL-TRANS-RETINAL manufacturers

  • Retinaldehyde
  • $10.00 / 1Kg/Drum
  • 2023-03-06
  • CAS:116-31-4
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10 ton
  • All-trans-retinal
  • $10.00 / 1kg
  • 2023-02-13
  • CAS:116-31-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 50MT
  • alltransretinal
  • $0.00 / 25KG
  • 2022-02-25
  • CAS:116-31-4
  • Min. Order: 2KG
  • Purity: 98% up by hplc
  • Supply Ability: 20 tons
ALL-TRANS-RETINAL Basic information
Synonyms:2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-;2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-;all-E-Retinal;all-trans-retina;All-trans-Retinaldehyde;alpha-Retinene;Axerophthal;E-Retinal
Product Categories:Vitamins;Aldehydes;Antitumor Agents;Building Blocks;C13-C60;Cancer Research;Carbonyl Compounds;Chemical Synthesis;Cofactor;Gene Regulation;Isoprenoid;Metabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Metabolomics;Nutrition Research;Organic Building Blocks;Vitamin A;Retinoids;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:116-31-4.mol
ALL-TRANS-RETINAL Chemical Properties
Melting point 61-63°C
Boiling point 366.92°C (rough estimate)
density 1.0083 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form powder
color yellow
Water Solubility <70mg/L(25 ºC)
Stability:Hygroscopic, Light Sensitive, Temperature Sensitive
CAS DataBase Reference116-31-4(CAS DataBase Reference)
EPA Substance Registry SystemRetinal (116-31-4)
Safety Information
Hazard Codes Xn
Risk Statements 22-38
Safety Statements 22-36/37
WGK Germany 3
RTECS VH6407000
HS Code 29122990
MSDS Information
SigmaAldrich English
ALL-TRANS-RETINAL Usage And Synthesis
Chemical PropertiesYellow Powder
UsesAll trans-Retinal has been used:
  • in optogenetic experiments
  • in electrophysiological experiment
  • to study the effect of AKR1B10 (aldo-keto reductase (AKR) superfamily member) on the conversion of retinal to retinol in the airway epithelium
  • in decidual transformation of human endometrial stromal cells
Usesretinaldehyde is a mild retinoid credited with increasing epidermal thickness without producing erythema.
UsesCorotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase.
DefinitionChEBI: A retinal in which all four exocyclic double bonds have E- (trans-) geometry.
Synthesis Reference(s)Tetrahedron Letters, 29, p. 419, 1988 DOI: 10.1016/S0040-4039(00)80111-2
General DescriptionAll trans-Retinal is one of the major derivatives of vitamin A group. A variety of food serves as a source of vitamin A. It is predominant in liver and among the brightly colored vegetables.
Biological Activityall-trans retinal, also known as vitamin a aldehyde or retinaldehyde, is one of the many forms of vitamin a and also the oxidation product of all-trans retinol [1]. all-trans retinal are associated with one of the two isoforms of cellular retinol-binding proteins (crbp-i and crbp-ii) with kd values of 50 and 90 nm, respectively [1].crbp-i and crbp-ii were the first intracellular retinoid-binding proteins. both proteins display a similar binding affinity towards retinal. they play important roles in retinoid biology and regulation of the metabolism of retinol and retinal. crbp-i is used to regulate vitamin a storage and synthesis of retinoic acid. and crbp-ii has a role in the initial processing of retinol from food [1].all-trans retinal is one form of vitamin a. all-trans retinal, the initial substrate of retinoid cycle, is a chemically reactive aldehyde that can form toxic conjugates with proteins and lipids, leading to degeneration of the retina [2].
Biochem/physiol ActionsAll-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. Retinal isomers are also chromophores that bind to opsins, a family of G-protein-linked transmembrane proteins, to form photosensitive receptors in visual and nonvisual systems. All-trans retinal is a potent photosensitizer.
Purification MethodsThe aldehyde is separated from retinol by column chromatography on water-deactivated alumina. Elute with 1-2% acetone in hexane, or on TLC plates of silica gel G and using the same eluting solvent. It crystallises from pet ether or n-hexane as yellow-orange crystals, and the UV in hexane has max at 373nm (A1cm 1% 1,548) and 368nm ( 48,000). It is an irritant and is light sensitive. Store it in sealed ampoules under N2. The semicarbazone forms yellow crystals from CHCl3/Et2O or EtOH, m 199-201o(dec). The 9-cis-isomer [514-85-2] and the 13-cis-isomer [472-86-6] [max at 375nm ( 1,250) in EtOH] are also available commercially. [Beilstein 7 III 1742.]
references[1]. noy n. retinoid-binding proteins: mediators of retinoid action. biochem j. 2000 jun 15;348 pt 3:481-95.
[2]. kiser pd, golczak m, maeda a, et al. key enzymes of the retinoid (visual) cycle in vertebrate retina. biochim biophys acta. 2012 jan;1821(1):137-51.
ALL-TRANS-RETINAL Preparation Products And Raw materials
Raw materialsVitamin A-->EC
Preparation Products9-CIS-RETINAL
Tag:ALL-TRANS-RETINAL(116-31-4) Related Product Information
CHLOROPHYLL Disinfectant Vitamin A 3-Cyclohexene-1,2-dimethanol, 3,6-dimethyl-5-[2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadienyl]-6-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatrienyl]-, cis-2,cis-5- (8CI) Kitol Diacetate(Mixture of Diastereomers) 9-cis-Retinyl Palmitate Vitamin E COENZYME Vitamin A palmitate Nicotinic acid Folic acid β-Carotene Ascorbic Acid Collagen TOCORRETINATE RETINOIC ACID ALL TRANS [11,12-3H] RETINOIC ACID ALL TRANS, [20 METHYL-3H] all-trans Retinoic Acid-D5 Ethyl Ester