5,8,11-EICOSATRIYNOIC ACID manufacturers
- ETI
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- $10.00 / 1kg
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2022-10-22
- CAS:13488-22-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: Ex 20 tons
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| | 5,8,11-EICOSATRIYNOIC ACID Basic information |
| Product Name: | 5,8,11-EICOSATRIYNOIC ACID | | Synonyms: | 5,8,11-Icosatriynoic acid;5,8,11-EICOSATRIYNOIC ACID;OWYNLPMPYBYKJP-UHFFFAOYSA-N;Icosa-5,8,11-triynoic acid;5,8,11-EICOSATRIYNOIC ACID Basic information;5,8,11-EICOSATRIYNOIC ACID ISO 9001：2015 REACH;EICOSATRIYNOIC ACID;ETI | | CAS: | 13488-22-7 | | MF: | C20H28O2 | | MW: | 300.44 | | EINECS: | 200-533-0 | | Product Categories: | | | Mol File: | 13488-22-7.mol |  |
| | 5,8,11-EICOSATRIYNOIC ACID Chemical Properties |
| Melting point | 70.5-71.5 °C | | Boiling point | 473.8±40.0 °C(Predicted) | | density | 0.990±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Off-white solid. | | pka | 4.61±0.10(Predicted) | | color | Pale Yellow to Pale Beige | | Stability: | Light Sensitive |
| | 5,8,11-EICOSATRIYNOIC ACID Usage And Synthesis |
| Uses | ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor. | | Definition | ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions. | | Biological Activity | 5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2]. | | references | [1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6. |
| | 5,8,11-EICOSATRIYNOIC ACID Preparation Products And Raw materials |
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