|
|
| | 3-Chloropropylamine hydrochloride Basic information |
| | 3-Chloropropylamine hydrochloride Chemical Properties |
| Melting point | 145-150 °C(lit.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Crystalline Powder or Chunks | | color | Off-white to yellow-beige | | BRN | 3667451 | | InChI | InChI=1S/C3H8ClN.ClH/c4-2-1-3-5;/h1-3,5H2;1H | | InChIKey | IHPRVZKJZGXTBQ-UHFFFAOYSA-N | | SMILES | C(CCl)CN.Cl | | CAS DataBase Reference | 6276-54-6(CAS DataBase Reference) |
| | 3-Chloropropylamine hydrochloride Usage And Synthesis |
| Chemical Properties | off-white to yellow-beige crystalline | | Uses | 3-Chloropropylamine hydrochloride was used in chemical treatment of carbon-enriched fly ash concentrates. It was used in the synthesis of linear, star and comb-like polyacrylamides by atomic transfer radical polymerization. It was used in the synthesis of halogen-functionalized aliphatic polyketones (macroinitiators). | | Synthesis | General procedure for the synthesis of 3-chloropropylamine hydrochloride from 3-amino-1-propanol: An anhydrous chloroform (30 mL) solution of thionyl chloride (8.68 g, 1.32 mmol) was slowly added dropwise to 3-amino-1-propanol (4.49 g, 59.19 mmol) at 0-10°C. The reaction mixture was heated to room temperature and refluxed for 3 hours. The reaction mixture was gradually warmed to room temperature and then heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration to afford the target product 3-chloropropylamine hydrochloride (7.07 g, 55.15 mmol, 93% yield) as a green solid. Electrospray mass spectrometry (ESMS) showed m/z 94 ([M+H]+). | | References | [1] Patent: WO2014/18571, 2014, A2. Location in patent: Paragraph 00463
[2] Patent: WO2014/18570, 2014, A1. Location in patent: Paragraph 00261
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 19, p. 5413 - 5417
[4] Angew. Chem., 2018, vol. 130, p. 5511 - 5515,5 |
| | 3-Chloropropylamine hydrochloride Preparation Products And Raw materials |
|