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3B Pharmachem (Wuhan) International Co.,Ltd.
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Product Name:ACPT-I;(1S,3R,4S)-1-AMinocyclopentane-1,3,4-tricarboxylicacid
CAS:194918-76-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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| Products Intro: |
Product Name:ACPT-I
CAS:194918-76-8
Purity:98% by HPLC Remarks:ACPT-I, a competitive antagonist for mGluRs, has been found to exhibit anticonvulsant activities.
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EMMX Biotechnology LLC
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888-539-0666 |
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Product Name:ACPT-I
CAS:194918-76-8
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:ACPT-I
CAS:194918-76-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Product Name: | ACPT-I | | Synonyms: | ACPT-I;4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID;(1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID;1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)-;ACPT I,ACPTI | | CAS: | 194918-76-8 | | MF: | C8H11NO6 | | MW: | 217.18 | | EINECS: | | | Product Categories: | | | Mol File: | 194918-76-8.mol |  |
| | ACPT-I Chemical Properties |
| Boiling point | 440.4±45.0 °C(Predicted) | | density | 1.651±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH | | form | Powder | | pka | 1.85±0.60(Predicted) |
| | ACPT-I Usage And Synthesis |
| Description | ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor. | | Uses | ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs). | | Biological Activity | Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice. | | storage | Desiccate at -20°C |
| | ACPT-I Preparation Products And Raw materials |
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