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| | Tomatidine hydrochloride Basic information |
| | Tomatidine hydrochloride Chemical Properties |
| Melting point | 281-284°C (dec.) | | storage temp. | 2-8°C | | solubility | Methanol (Slightly) | | form | Off-white solid | | color | White to Off-White | | BRN | 3920740 |
| | Tomatidine hydrochloride Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid). | | Biological Activity | Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway. | | Mode of action | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans. |
| | Tomatidine hydrochloride Preparation Products And Raw materials |
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