L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
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L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:PROTACs Related Compound 4;(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2);(S,R,S)-AHPC-C8-NH2;(2S,4R)-1-((S)-2-(9-aminononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;VH032-C8-NH2;VH032-C7-NH2;L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(9-Aminononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide , (S,R,S)-AHPC-C8-NH2
CAS:2341796-79-8
MF:C31H47N5O4S
MW:585.8
EINECS:
Product Categories:
Mol File:2341796-79-8.mol
L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 844.3±65.0 °C(Predicted)
density 1.177±0.06 g/cm3(Predicted)
form Solid
pka14.08±0.40(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
Uses(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].
IC 50VHL
References[1] Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.
L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Tag:L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2341796-79-8) Related Product Information
(S,R,S)-Ahpc-C6-NH2 VH 032-linker 11 (2S,4R)-1-((S)-2-(9-aminononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride VH032-C10-NH2 L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-