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5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine

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5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Suppliers list
Company Name: ChemeGen 中国  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
CAS:2253745-70-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
CAS:2253745-70-7
Purity:98% Package:250μg;500μg;1mg
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
Products Intro: Product Name:5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
CAS:2253745-70-7
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Basic information
Product Name:5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
Synonyms:5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine;2-Pyrimidinamine, 5-butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-
CAS:2253745-70-7
MF:C27H27N3O
MW:409.52
EINECS:
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Mol File:2253745-70-7.mol
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Structure
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Chemical Properties
Boiling point 643.3±65.0 °C(Predicted)
density 1.139±0.06 g/cm3(Predicted)
solubility Chloroform: 10 mg/ml; Ethanol: 10 mg/ml; Methyl Acetate: 1 mg/ml
pka3.66±0.10(Predicted)
Safety Information
MSDS Information
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Usage And Synthesis
Description5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).1 It inhibits LPS-induced prostaglandin E2 (PGE2; ) production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
References1. Kal?ic, F., Kolman, V., Ajani, H., et al. Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edema ChemMedChem 15(15),1398-1407(2020).
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine Preparation Products And Raw materials
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