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oxyphenisatine di(acetate)

oxyphenisatine di(acetate) Suppliers list
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Products Intro: Product Name:oxyphenisatine di(acetate)
CAS:115-33-3
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Products Intro: Product Name:oxyphenisatine di(acetate)
CAS:115-33-3
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Products Intro: Product Name:Oxyphenisatin acetate
CAS:115-33-3
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CAS:115-33-3
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Products Intro: Product Name:Oxyphenisatin acetate
CAS:115-33-3
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oxyphenisatine di(acetate) manufacturers

oxyphenisatine di(acetate) Basic information
Product Name:oxyphenisatine di(acetate)
Synonyms:oxyphenisatine di(acetate);OXYPHENISATIN ACETATE;Isapheninum;Isaphenin;3,3-Bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one;Isocrin;Levema;NSC-59687
CAS:115-33-3
MF:C24H19NO5
MW:401.41
EINECS:204-083-6
Product Categories:
Mol File:115-33-3.mol
oxyphenisatine di(acetate) Structure
oxyphenisatine di(acetate) Chemical Properties
Melting point 244℃
Boiling point 566.5±50.0 °C(Predicted)
density 1.282±0.06 g/cm3(Predicted)
pka13.55±0.40(Predicted)
Safety Information
ToxicityLD50 oral in rat: 1900mg/kg
MSDS Information
oxyphenisatine di(acetate) Usage And Synthesis
OriginatorLavema,Winthrop,US,1959
UsesLaxative.
Manufacturing Process235 gravimetrical parts of acetic acid anhydride (90%) are poured over 106 gravimetrical parts of diphenolisatin (Berichte der Deutschen Chemischen Gesselschsft, 18, 1885, p. 2641) and the mixture is heated on the water-bath while stirring. The solid starting material temporarily dissolves almost entirely and shortly afterwards the reaction product turns into a crystalline paste. In order to complete the reaction the heating on the water-bath is continued for a short time and then the whole is left to get cold. The reaction product may, for instance, be separated in the following manner: To the cold reaction mixture is gradually added about the same volumetrical quantity of alcohol; in this manner the excess of acetic acid anhydride is destroyed and the paste becomes thinner. Then the fluid is drawn off and the product washed with alcohol. For complete cleansing another extraction is made with warm alcohol and the product crystallized, for instance, from 10 parts of acetic acid. The product represents a light, fine crystalline powder, which is difficultly soluble or even insoluble in the usual organic solvents. Its melting point lies at 242°C.
Brand nameIsocrin (Parke-Davis); Lavema (Sterling Winthrop);Acelax;Acetalax;Alophen pills;Ameiax;Api-slender;Artzone;Belloform;Biivectan;Bisflatan;Boxogetten;Brocatine;Buta pirone;Buteril;Butofen;Butolfen;Bydolax;Chlofel;Chur-lax;Ciracen;Cirotex;Cirotyl;Contax;Critex;Curolax;Darmoletten;Deililax;Dialose plus;Diasatin;Ditinil;Ditmedol;Eulaxin;Evac-u-lax;Ex-lax pills;Febutolo;Fibutrox;Fim-a-mint;Fin-a-mint gum;Fisiolax;Flib 518;Inlax;Ipebutona;Isaaxan;Isaphenyn;Izaman;Laveman;Laxan-vomoxin;Laxaseptol;Laxem;Laxnormal;Laxocoleva;Laxon;Laxos;Laxyl;Med-laxan;Menabil complex;Muxol;Naleran;Neocervulax;Neo-favmadol;Neo-soldana;Nourilax;Nurilaksi;Obstilax;Otone;Oxybutazone;Phlogase;Phlogistol;Phlogont;Potsilo;Promassoletten;Prusol;Rheumapax;Rivolax;Schokilax;Syndian;Tanderil-alka;Tete-lax;Validil.
Therapeutic FunctionLaxative
World Health Organization (WHO)Oxyphenisatine acetate was widely used as a laxative after its cathartic activity was first described in 1925. In 1969 its use was first associated with cases of acute and chronic liver disease. This association is considered by some, but not all, national drug regulatory authorities to warrant the withdrawal from the market of preparations containing oxyphenisatine and its derivatives.
oxyphenisatine di(acetate) Preparation Products And Raw materials
Raw materials3,3-BIS(P-HYDROXYPHENYL)OXINDOLE-->Acetic anhydride-->Oxyphenonium bromide
Tag:oxyphenisatine di(acetate)(115-33-3) Related Product Information
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