9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯
中文名称 | 9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯 |
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中文同义词 | 9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯;氯地米松-17 - 单丙酸酯;倍氯米松双丙酸酯EP杂质H;丙酸倍氯米松杂质H(EP);倍氯米松杂质H;倍氯米松-17-单丙酸酯对照品;倍氯米松 17-丙酸酯;丙酸倍氯米松杂质H(EP) 标准品 |
英文名称 | 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate |
英文同义词 | 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate;beclomethasone 17-monopropionate;9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propanoate;9-Chloro-11,21-dihydroxy-16-methyl-17-propionyloxypregna-1,4-diene-3,20-dione;9-Chloro-11β,21-dihydroxy-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione;9-Chloro-11β-hydroxy-16β-methyl-17α-(propionyloxy)-21-hydroxypregna-1,4-diene-3,20-dione;9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate;Beclomethasone EP Impurity H |
CAS号 | 5534-18-9 |
分子式 | C25H33ClO6 |
分子量 | 464.97892 |
EINECS号 | 2268881 |
相关类别 | Metabolites & Impurities;Steroids |
Mol文件 | 5534-18-9.mol |
结构式 |
9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯 性质
熔点 | 124-126?C |
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沸点 | 608.9±55.0 °C(Predicted) |
密度 | 1.30±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 二甲基亚砜:100 mg/mL(215.06 mM) |
形态 | 固体 |
酸度系数(pKa) | 12.98±0.10(Predicted) |
颜色 | 白色至浅黄色至浅橙色 |
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate) 是 Beclomethasone dipropionate (HY-13571) 的活性代谢产物,是糖皮质激素受体 (GR) 激动剂。Beclomethasone 17-propionate 对 GR 的亲和力比 Beclomethasone dipropionate 高。Beclomethasone 17-propionate 有效抑制慢性阻塞性肺疾病 (COPD) 肺巨噬细胞中细胞因子的产生。
Metabolism of Beclomethasone dipropionate to 17-BMP is an important activation step. Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα and IL-6. The EC 50 values of Beclomethasone 17-propionate for IL-6, TNFα and CXCL8 were 0.05 nM, 0.01 nM and 0.1 nM, respectively. Beclomethasone 17-propionate evokes upregulation of the GR dependent genes FKBP51 and GILZ.
用途
倍氯米松双丙酸酯的中间体。安全信息
海关编码 | 29162090 |
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