| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:RB-3
CAS:2396639-11-3
Package:25mg/RMB 14400
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1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- manufacturers
- RB-3
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- $2120.00 / 25mg
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2025-04-30
- CAS:2396639-11-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- Basic information |
| | 1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- Chemical Properties |
| Boiling point | 717.4±60.0 °C(Predicted) | | density | 1.403±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 4.11±0.50(Predicted) | | form | Solid | | color | White to light yellow |
| | 1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- Usage And Synthesis |
| Uses | RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1]. | | Biological Activity | RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1].RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1].RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1].RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. | | References | [1]. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793. |
| | 1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- Preparation Products And Raw materials |
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