- Leptomycin A
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- $210.00 / 100μg
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2025-07-23
- CAS:87081-36-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | LEPTOMYCIN A Basic information |
| Product Name: | LEPTOMYCIN A | | Synonyms: | ATS 1287A, PD 118607, JildaMycin;NSC 369326;2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;Antibiotic ATS-1287A;Antibiotic PD-118607;PD-118607 | | CAS: | 87081-36-5 | | MF: | C32H46O6 | | MW: | 526.7 | | EINECS: | | | Product Categories: | ADC | | Mol File: | 87081-36-5.mol |  |
| | LEPTOMYCIN A Chemical Properties |
| Fp | 9℃ | | storage temp. | -20°C | | solubility | Ethanol: Soluble; Methanol: Soluble | | form | methanol solution | | color | Colorless to light yellow |
| | LEPTOMYCIN A Usage And Synthesis |
| Description | Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent. | | Uses | Leptomycin A is an antifungal antibiotic. | | Uses | Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. | | Definition | ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17. | | IC 50 | HIV-1 | | References | [1] NOBUAKI KUDO . Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1[J]. Experimental cell research, 1998, 242 2: Pages 540-547. DOI: 10.1006/excr.1998.4136
[2] YING WANG. Novel leptomycins from a streptomyces strain A92-308902: Inhibitors of the Nucleo-cytoplasmic translocation of the HIV-1 regulatory protein Rev[J]. Helvetica Chimica Acta, 2004, 80 7: 2157-2167. DOI: 10.1002/hlca.19970800715 |
| | LEPTOMYCIN A Preparation Products And Raw materials |
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