| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:SR15006
CAS:2505001-54-5
Purity:98% Package:5mg Remarks:S89454
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2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- manufacturers
- SR15006
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- $41.00 / 10mg
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2025-11-09
- CAS:2505001-54-5
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
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| | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Basic information |
| Product Name: | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- | | Synonyms: | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-;growth,inhibit,KLF5,SR 15006,Krüppel-like factor,SR15006,colorectal cancer cells,cycle,Inhibitor,KLF,cyclins,SR-15006;(2E)-3-(3-chlorophenyl)-N-[2-(4-methanesulfonylpiperazin-1-yl)-2-oxoethyl]prop-2-enamide;SR15006, 10 mM in DMSO;(E)-3-(3-Chlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide | | CAS: | 2505001-54-5 | | MF: | C16H20ClN3O4S | | MW: | 385.87 | | EINECS: | | | Product Categories: | | | Mol File: | 2505001-54-5.mol | ![2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Structure](CAS/20210305/GIF/2505001-54-5.gif) |
| | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (259.15 mM; Need ultrasonic) | | pka | 13.21±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Usage And Synthesis |
| Uses | SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells)[1]. | | Biological Activity | SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells)[1].
SR15006 (1 μM or 10 μM; DLD-1 CRC cells) causes a significant reduction in the levels of tested cyclins over the course of 72 hours[1]. | | References | [1]. Kim J, et al. The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. Mol Cancer Ther. 2019;18(11):1973-1984. |
| | 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)- Preparation Products And Raw materials |
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