| Company Name: |
Chengdu Youngshe Chemical Co., Ltd.
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| Tel: |
+86-17380623303 |
| Email: |
Caroline@youngshechem.com |
| Products Intro: |
Product Name:Alirinetide
CAS:725715-18-4
Purity:95% Package:1G; 10G; 100G
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GM-608 manufacturers
- GM-608
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- $0.00 / 100mg
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2025-10-27
- CAS:725715-18-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | GM-608 | | Synonyms: | L-Arginine, L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl-;GM-605;GM-602;GM-603;GM-604;GM-606;GM-607;GM-608 | | CAS: | 725715-18-4 | | MF: | C36H54N12O9 | | MW: | 798.89 | | EINECS: | | | Product Categories: | | | Mol File: | 725715-18-4.mol |  |
| | GM-608 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | pka | 3.34±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | GM-608 Usage And Synthesis |
| Uses | Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases[1]. | | in vivo | Alirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model[1]. | Animal Model: | C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model[1] | | Dosage: | 0, 1, 5, 10 or 20 mg/kg | | Administration: | Intravenous injection, twice daily for 5 days | | Result: | Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and
homovanillic acid (HVA).
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| | References | [1] Swindell W R, et al. GM604 for Parkinson's Disease treatment: Pre-clinical findings and results from a pilot placebo-controlled trial. F1000Research, 2017, 6. |
| | GM-608 Preparation Products And Raw materials |
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