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MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
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Products Intro: Product Name:MECLOFENAMATE SODIUM
CAS:6385-02-0
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:6385-02-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: CONIER CHEM AND PHARMA LIMITED
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Email: sales@conier.com
Products Intro: CAS:6385-02-0
Purity:0.99 Package:1kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: 13772537765
Email: 1010@dideu.com
Products Intro: Product Name:SodiuM MeclofenaMate Monohydrate
CAS:6385-02-0
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
Company Name: Target Molecule Corp
Tel: 781-999-5354 18019718960
Email: marketing@targetmol.com
Products Intro: Product Name:Meclofenamate Sodium;Meclomen;Meclonax;Movens;Movens
CAS:6385-02-0
Purity:99.08% Package:25 mg;50 mg;100 mg;200 mg;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY

MECLOFENAMATE SODIUM manufacturers

MECLOFENAMATE SODIUM Basic information
Product Name:MECLOFENAMATE SODIUM
Synonyms:MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE;Sodium Meclofenamate Monohydrate;C02996;sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate;SODIUM MECLOFENAMATE;meclofenamic acid sodium;MECLOFENAMIC ACID SODIUM SALT 99%;Meclofenamate
CAS:6385-02-0
MF:C14H10Cl2NO2.Na
MW:318.13
EINECS:228-983-3
Product Categories:MECLOMEN
Mol File:6385-02-0.mol
MECLOFENAMATE SODIUM Structure
MECLOFENAMATE SODIUM Chemical Properties
Melting point 287-291 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form White solid.
Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck 14,5779
Safety Information
WGK Germany 3
RTECS CB2975500
HS Code 2922498050
MSDS Information
ProviderLanguage
SigmaAldrich English
MECLOFENAMATE SODIUM Usage And Synthesis
OriginatorMeclomen,Warner Lambert,US,1980
Usesantiinflammatory, antipyretic
DefinitionChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
IndicationsMeclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
Manufacturing ProcessA mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
Brand nameMeclomen (Parke-Davis).
Therapeutic FunctionAntiinflammatory
General DescriptionMeclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
PharmacokineticsMeclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg
Clinical UseMeclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.
MECLOFENAMATE SODIUM Preparation Products And Raw materials
Raw materials2,6-Dichloro-3-methylaniline-->N-Ethylmorpholine
Tag:MECLOFENAMATE SODIUM(6385-02-0) Related Product Information
MCPA SODIUM N-Phenylanthranilic acid 2-Chloro-5-methylaniline CLOFENAMIC ACID MECLOFENAMATE SODIUM USP(CRM STANDARD) Meclofenamic acid 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE SODIUM ANTHRANILATE (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine. N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID MECLOFENAMATE SODIUM 2,6-DICHLORODIPHENYLAMINE 2-[(2-Chlorophenyl)amino]-benzaldehyde