| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride
CAS:2490508-82-0
Purity:98% Package:5mg;10mg;25mg;50mg;100mg Remarks:BD02216867
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Syk Inhibitor II hydrochloride
CAS:2490508-82-0
Purity:98.00% Package:1mg;5mg;10mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Syk Inhibitor II hydrochloride
CAS:2490508-82-0
Purity:98.17% Package:1mg/RMB 321;5mg/RMB 712;10mg/RMB 1330
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5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride (1:1) manufacturers
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| | 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride (1:1) Basic information |
| | 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride (1:1) Chemical Properties |
| | 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride (1:1) Usage And Synthesis |
| Uses | Syk Inhibitor II hydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II hydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II hydrochloride shows less potent against other kinases and has anti-allergic effect[1]. | | in vivo | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) hydrochloride is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1]. | Animal Model: | ICR mice[1] | | Dosage: | 10, 30, 100 mg/kg | | Administration: | S.c.; 30 min before antigen challenge | | Result: | Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg. |
| | IC 50 | 5-HT Receptor: 460 nM (IC50) | | References | [1] Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DOI:10.1016/j.bmc.2005.05.033 |
| | 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride (1:1) Preparation Products And Raw materials |
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