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| | 2-Methyl-2-thiopseudourea sulfate Basic information |
| | 2-Methyl-2-thiopseudourea sulfate Chemical Properties |
| Melting point | 240-241 °C (dec.)(lit.) | | density | 1.28 | | Fp | 3℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: 0.1 g/mL, clear, colorless | | pka | pK1:9.83(＋1) (25°C) | | form | Crystals or Crystalline Powder | | color | White | | PH | 5.5 (260g/l, H2O, 20℃) | | Water Solubility | 260 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 3917217 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 867-44-7(CAS DataBase Reference) | | EPA Substance Registry System | Carbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | UM9200000 | | TSCA | Yes | | HS Code | 29309070 |
| | 2-Methyl-2-thiopseudourea sulfate Usage And Synthesis |
| Description | SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively. | | Chemical Properties | white crystalline powder | | Uses | Intermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity. | | Biochem/physiol Actions | More potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). |
| | 2-Methyl-2-thiopseudourea sulfate Preparation Products And Raw materials |
| Preparation Products | 5-methoxy-2-(methylthio)pyrimidin-4-ol ,97%-->4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97%-->1-Methyl-3-nitro-1-nitrosoguanidine-->ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE-->Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate-->Aminoguanidine bicarbonate-->1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER-->IMINOCTADINE TRIACETATE-->5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID-->1,1-DIMETHYLGUANIDINE SULFATE-->5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE-->5-Chloro-2-(methylsulfonyl)pyrimidine-->METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97-->4-Methoxy-6-methyl-2-(methylsulfonyl)pyrimidine ,97%-->5-CHLORO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%-->5-BROMO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%-->4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile-->3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER-->5-AMINOPYRIMIDINE-->5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid-->ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate-->4-Methoxy-6-methyl-2-(methylthio)pyrimidine-->4-METHYL-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER-->2-(METHYLSULFANYL)-5-PHENYLPYRIMIDINE-->5-Methyl-2-(methylsulfonyl)pyrimidine ,97%-->Aminoguanidinium sulphate-->2-(METHYLTHIO)ETHANOL-->1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE-->Gabexate mesylate-->4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID-->ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->5-METHYL-2-METHYLSULFANYL-PYRIMIDINE |
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